Cerebrospinal fluid leakage is a frequent complication after cranial and spinal surgery. To prevent this complication and seal the dura watertight, we developed Liqoseal, a dural sealant patch comprising a watertight polyesterurethane layer and an adhesive layer consisting of poly(DL-lactide-co-ε-caprolactone) copolymer and multiarmed N-hydroxylsuccinimide functionalized polyethylene glycol. We compared acute burst pressure and resistance to physiological conditions for 72 h of Liqoseal, Adherus, Duraseal, Tachosil, and Tisseel using computer-assisted models and fresh porcine dura. The mean acute burst pressure of Liqoseal in the cranial model (145 ± 39 mmHg) was higher than that of Adherus (87 ± 47 mmHg), Duraseal (51 ± 42 mmHg) and Tachosil (71 ± 16 mmHg). Under physiological conditions, cranial model resistance test results showed that 2 of 3 Liqoseal sealants maintained dural attachment during 72 hours as opposed to 3 of 3 for Adherus and Duraseal and 0 of 3 for Tachosil. The mean burst pressure of Liqoseal in the spinal model (233 ± 81 mmHg) was higher than that of Tachosil (123 ± 63 mmHg) and Tisseel (23 ± 16 mmHg). Under physiological conditions, spinal model resistance test results showed that 2 of 3 Liqoseal sealants maintained dural attachment for 72 hours as opposed to 3 of 3 for Adherus and 0 of 3 for Duraseal and Tachosil. This novel study showed that Liqoseal is capable of achieving a strong watertight seal over a dural defect in ex vivo models.

脑脊液漏是颅脑和脊柱手术后常见的并发症。为了防止这种并发症并密封硬脑膜不透水，我们开发了 Liqoseal，这是一种硬脑膜密封贴片，包括防水的聚酯聚氨酯层和由聚（DL-丙交酯-共-ε-己内酯）共聚物和多臂 N-羟基琥珀酰亚胺官能化聚乙二醇组成的粘合剂层. 我们使用计算机辅助模型和新鲜猪硬脑膜比较了 Liqoseal、Adherus、Duraseal、Tachosil 和 Tisseel 72 小时的急性爆破压力和对生理条件的抵抗力。Liqoseal 在颅骨模型中的平均急性爆破压力 (145 ± 39 mmHg) 高于 Adherus (87 ± 47 mmHg)、Duraseal (51 ± 42 mmHg) 和 Tachosil (71 ± 16 mmHg)。在生理条件下，颅骨模型阻力测试结果显示，3 种 Liqoseal 密封剂中有 2 种在 72 小时内保持硬脑膜附着，而 Adherus 和 Duraseal 为 3 种中的 3 种，Tachosil 为 3 种中的 0 种。Liqoseal 在脊柱模型中的平均爆破压力 (233 ± 81 mmHg) 高于 Tachosil (123 ± 63 mmHg) 和 Tisseel (23 ± 16 mmHg)。在生理条件下，脊柱模型阻力测试结果表明，3 种 Liqoseal 密封剂中有 2 种维持硬脑膜附着 72 小时，而 Adherus 为 3 种中的 3 种，Duraseal 和 Tachosil 为 3 种中的 0 种。这项新颖的研究表明，Liqoseal 能够在离体模型中的硬脑膜缺损处实现强大的防水密封。Liqoseal 在脊柱模型中的平均爆破压力 (233 ± 81 mmHg) 高于 Tachosil (123 ± 63 mmHg) 和 Tisseel (23 ± 16 mmHg)。在生理条件下，脊柱模型阻力测试结果表明，3 种 Liqoseal 密封剂中有 2 种维持硬脑膜附着 72 小时，而 Adherus 为 3 种中的 3 种，Duraseal 和 Tachosil 为 3 种中的 0 种。这项新颖的研究表明，Liqoseal 能够在离体模型中的硬脑膜缺损处实现强大的防水密封。Liqoseal 在脊柱模型中的平均爆破压力 (233 ± 81 mmHg) 高于 Tachosil (123 ± 63 mmHg) 和 Tisseel (23 ± 16 mmHg)。在生理条件下，脊柱模型阻力测试结果表明，3 种 Liqoseal 密封剂中有 2 种维持硬脑膜附着 72 小时，而 Adherus 为 3 种中的 3 种，Duraseal 和 Tachosil 为 3 种中的 0 种。这项新颖的研究表明，Liqoseal 能够在离体模型中的硬脑膜缺损处实现强大的防水密封。