Extracellular vesicles (EVs) either as endocytic or plasma membrane-emerged vesicles play pivotal role in cell-to-cell communication. Due to the bioactive molecules transformation, lymphoma cell-derived vesicles can alter a recipient cell's function and contribute to signal transduction and drug resistance. These vesicles by acting not only in tumor cells but also in tumor-associated cells have important roles in tumor growth and invasion. On the other hand, the total protein level of circulating exosomes reveals the disease stage, tumor burden, response to therapy, and survival. In residual disease, leukemic blasts are undetectable in the bone marrow by conventional methods but exosomal proteins are elevated significantly. In this manner, new methods for measuring exosomes and exosomal components are required. In this review, we try to reveal the concealed role of EVs in hematological malignancies besides therapeutic potentials.

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细胞外囊泡：血液系统恶性肿瘤的再生医学前景

胞外囊泡 (EV) 作为内吞或质膜出现的囊泡在细胞间通讯中发挥着关键作用。由于生物活性分子的转化，淋巴瘤细胞衍生的囊泡可以改变受体细胞的功能，并有助于信号转导和耐药性。这些囊泡不仅作用于肿瘤细胞，而且作用于肿瘤相关细胞，在肿瘤生长和侵袭中具有重要作用。另一方面，循环外泌体的总蛋白水平揭示了疾病阶段、肿瘤负荷、对治疗的反应和存活率。在残留疾病中，通过常规方法在骨髓中无法检测到白血病原始细胞，但外泌体蛋白显着升高。以这种方式，需要测量外泌体和外泌体成分的新方法。在本次审查中，