Parkinson's disease (PD) is a severe neurodegenerative disease with high morbidity in the elderly population. 6-OHDA-induced cell senescence is reported to be involved in the pathogenesis of PD. Ramelteon is an oral hypnotic agent that specifically targets the receptors of the suprachiasmatic nucleus in the human hypothalamus. Here, an investigation is made to see whether Ramelteon possesses a beneficial effect against 6-OHDA-induced cellular senescence in human SH-SY5Y neuronal cells.

中文翻译：

---

Ramelteon 对 6-OHDA 诱导的人 SH-SY5Y 神经元细胞衰老的保护作用

帕金森病（PD）是一种严重的神经退行性疾病，在老年人群中发病率很高。据报道，6-OHDA 诱导的细胞衰老参与了 PD 的发病机制。Ramelteon 是一种口服催眠药，专门针对人类下丘脑中视交叉上核的受体。在这里，进行了一项调查，看看 Ramelteon 是否对人 SH-SY5Y 神经元细胞中 6-OHDA 诱导的细胞衰老具有有益作用。