Papers concerning transcription, and its regulation at promoters, abound in the scientific literature, but reports about initiation, defined as the moment that the first 3′−5′phosphodiester bond of a new transcript is forged, are scarce. In PNAS, Skalenko et al. (1), working with the bacterial multisubunit DNA-dependent RNA polymerase (RNAP), combine high-throughput DNA base-sequencing methods with structural analysis, to provide insights into how RNAP manages the two partner molecules needed to create that first bond, as each new RNA transcript is born.

中文翻译：

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随着转录的开始，RNA 聚合酶被宠坏了 [生物化学]

关于转录及其在启动子上的调控的论文在科学文献中比比皆是，但关于起始的报道（定义为新转录本的第一个 3'-5'磷酸二酯键形成的那一刻）却很少。在 PNAS 中，Skalenko 等人。( 1 ) 与细菌多亚基 DNA 依赖性 RNA 聚合酶 (RNAP) 合作，将高通量 DNA 碱基测序方法与结构分析相结合，以深入了解 RNAP 如何管理创建第一个键所需的两个伙伴分子，如每个新的 RNA 转录本都会诞生。