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The effect of VAV3 polymorphisms on thyroid cancer.
Endocrine ( IF 3.7 ) Pub Date : 2021-07-22 , DOI: 10.1007/s12020-021-02827-6 Wanli Ren 1 , Chongwen Xu 1 , Shiyang Wang 1 , Huajing Li 1 , Hao Dai 1 , Fangli Yang 1 , Yuan Shao 1 , Yanxia Bai 1
Endocrine ( IF 3.7 ) Pub Date : 2021-07-22 , DOI: 10.1007/s12020-021-02827-6 Wanli Ren 1 , Chongwen Xu 1 , Shiyang Wang 1 , Huajing Li 1 , Hao Dai 1 , Fangli Yang 1 , Yuan Shao 1 , Yanxia Bai 1
Affiliation
BACKGROUND
The incidence of thyroid cancer is rising rapidly in China, but there are few studies on the risk factors of thyroid cancer in the Chinese Han population.
METHODS
We performed this case-control study of 510 patients and 509 controls to for determine the linkage of VAV3 variants (rs17019602, rs7521681, rs4915076, and rs1777451) with thyroid cancer susceptibility by computing the odds ratio (OR) and 95% confidence intervals (CI). Multi-factor dimension reduction (MDR) analysis was conducted to assess interaction of VAV3 genetic variants.
RESULTS
We found that rs7521681 was remarkably related to a higher risk of thyroid cancer (OR = 1.74, p = 0.012), whereas rs4915076 (OR = 0.66, p = 0.001) significantly decreased thyroid cancer susceptibility. Stratified analyses showed that rs4915076 had a protective role in thyroid cancer in both ages >45 years (OR = 0.70, p = 0.017) and age ≤45 years (OR = 0.63, p = 0.007). Rs17019602 could increase the susceptibility of thyroid cancer in men (OR = 4.76, p = 0.049). Rs7521681 was related to an increased risk of thyroid cancer in women (OR = 1.97, p = 0.012). Rs4915076 could protect individuals from thyroid cancer both in men (OR = 0.60, p = 0.031) and women (OR = 0.68, p = 0.010). Moreover, rs4915076 was the best single-locus model to predict thyroid cancer. Interestingly, the interaction model of rs17019602, rs7521681, rs4915076, rs1777451, and age was a candidate gene-environment model.
CONCLUSION
Our results indicated VAV3 variants were associated with thyroid cancer, which provides a new sight into etiology of thyroid cancer.
更新日期：2021-07-22
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