The transcription factor Zinc finger E-box binding 1 (ZEB1) displays a range of regulatory activities in cell function and embryonic development, including driving epithelial-mesenchymal transition. Several aspects of ZEB1 function can be regulated by its functional interactions with noncoding RNA types, namely microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). Increasing evidence indicates that ZEB1 importantly influences cancer initiation, tumor progression, metastasis, and resistance to treatment. Cancer is the main disease-related cause of death in children and adolescents. Although the role of ZEB1 in pediatric cancer is still poorly understood, emerging findings have shown that it is expressed and regulates childhood solid tumors including osteosarcoma, retinoblastoma, neuroblastoma, and central nervous system tumors. Here, we review the evidence supporting a role for ZEB1, and its interplays with miRNAs and lncRNAs, in pediatric cancers.

转录因子 Zinc finger E-box binding 1 (ZEB1) 在细胞功能和胚胎发育中表现出一系列调节活性，包括驱动上皮-间质转化。ZEB1 功能的几个方面可以通过其与非编码 RNA 类型的功能相互作用来调节，即 microRNA (miRNA) 和长非编码 RNA (lncRNA)。越来越多的证据表明 ZEB1 对癌症的发生、肿瘤进展、转移和对治疗的抵抗有重要影响。癌症是儿童和青少年与疾病相关的主要死因。尽管 ZEB1 在儿科癌症中的作用仍然知之甚少，但新发现表明它表达并调节儿童实体瘤，包括骨肉瘤、视网膜母细胞瘤、神经母细胞瘤和中枢神经系统肿瘤。这里，