The relevance of subcortical structures and interhemispheric subcortical-cortical interactions among positive/negative affect and approach/withdrawal tendencies during resting-state are not fully understood. Gaining this knowledge may foster the know-how on their role in subsequent task-engagement and also on the interlinkage among affective measures and approach/withdrawal dichotomy. Here we performed a study based on Region of Interest (ROI)-based analysis and graph-theory estimates for global and subnetworks on a limited sample of healthy 50 male volunteers who recorded resting functional magnetic resonance imaging (fMRI) and self-reported measures of Positive and Negative Affect Schedule (PANAS) and BAS-BIS (Behavioral Activation System-Behavioral Inhibition System) scores. Our study's initial results of region of interest-to-region of interest (ROI-to-ROI) connectivity revealed the connectivity of subcortical neural substrates of PANAS and BAS-BIS scores with bilateralized cortical regions. However, on probing the lateralization of strength of degree measures of the cortical-regions vital for subcortical-cortical interaction, we found, for positive affect, a left-hemispheric proclivity. Further, higher connectivity within the left hemisphere was also observed for the left-lateralized critical cortical regions of negative affect. Our study also revealed the association of emotion and memory-related subcortical-cortical interactions in positive and negative affect. Right amygdala-right thalamus-frontotemporal cortical areas emanated in positive affect, and right putamen-left hippocampus-frontotemporal cortical regions network stemmed for negative affect. Then, we show the involvement of basal-ganglia structures in approach-withdrawal dichotomy with tight coupling of right-caudate, left-accumbens with anterior cingulate, and insular regions for withdrawal/inhibition system. Further, distinct involvement of the insula (posterior) in affective states while insula (anterior) in approach/withdrawal systems builds up for the existence of a feedback loop between affective and approach/withdrawal systems. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译：

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通过静息状态功能连接方法评估皮层下和皮层对影响和接近/退缩行为的不同贡献。

皮层下结构和半球间皮层下-皮层相互作用在静息状态期间积极/消极影响和接近/退缩倾向之间的相关性尚未完全了解。获得这些知识可能会促进他们在随后的任务参与中的作用以及情感措施和接近/退出二分法之间的相互联系的知识。在这里，我们进行了一项基于感兴趣区域 (ROI) 分析和图论估计的研究，对全球和子网的有限样本健康 50 名男性志愿者进行了记录，他们记录了静息功能磁共振成像 (fMRI) 和自我报告的测量值正面和负面影响表 (PANAS) 和 BAS-BIS（行为激活系统-行为抑制系统）评分。我们的研究' 感兴趣区域到感兴趣区域 (ROI-to-ROI) 连通性的初步结果揭示了 PANAS 和 BAS-BIS 评分的皮层下神经基质与双边皮层区域的连通性。然而，在探索对皮质下 - 皮质相互作用至关重要的皮质区域的程度测量强度的偏侧化时，我们发现，对于积极影响，左半球倾向。此外，对于负面影响的左侧关键皮层区域，还观察到左半球内更高的连通性。我们的研究还揭示了情绪和记忆相关的皮层下 - 皮层相互作用在积极和消极情绪中的关联。右侧杏仁核 - 右侧丘脑 - 额颞叶皮质区域散发出积极的影响，和右壳核-左海马-额颞叶皮质区域网络阻止了负面影响。然后，我们展示了基底神经节结构在入路-撤回二分法中的参与，右尾状核、左伏隔与前扣带回以及用于撤回/抑制系统的岛叶区域紧密耦合。此外，脑岛（后部）在情感状态中的明显参与，而岛叶（前部）在接近/退缩系统中的作用为情感和接近/退缩系统之间的反馈回路的存在而建立。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。和岛屿地区的撤退/抑制系统。此外，脑岛（后部）在情感状态中的明显参与，而岛叶（前部）在接近/退缩系统中的作用为情感和接近/退缩系统之间的反馈回路的存在而建立。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。和岛屿地区的撤退/抑制系统。此外，脑岛（后部）在情感状态中的明显参与，而岛叶（前部）在接近/退缩系统中的作用为情感和接近/退缩系统之间的反馈回路的存在而建立。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。