Optical coherence tomography (OCT)-angiography coregistration during stent implantation may be useful to avoid geographical mismatch and incomplete lesion coverage. Untreated lipid-rich plaque at stent edge is associated with subsequent stent edge restenosis. The present study sought to compare the frequency of untreated lipid-rich plaque at the stent edge between OCT-guided percutaneous coronary intervention (PCI) with and without OCT-angiography coregistration. We investigated 398 patients who underwent OCT-guided stent implantation (n = 198 in the coregistration group, and n = 200 in the no coregistration group). In OCT after PCI, untreated lipid-lich plaque was identified by the maximum lipid arc > 180˚ in the 5-mm stent edge segment. The PCI-targeted lesion characteristics and stent length were not different between the coregistration group and the no coregistration group. The frequency of untreated lipid-rich plaque in either proximal or distal stent edge segment was significantly lower in the coregistration group than in the no coregistration group (16% vs. 26%, P = 0.015). The frequency of stent-edge dissection (5% vs. 6%, P = 0.516) and untreated stenosis (2% vs. 3%, P = 0.724) was low and without significant differences between the two groups. In OCT-guided PCI, the use of OCT-angiography coregistration was associated with a reduced frequency of untreated lipid-rich plaque at stent edges. OCT-angiography coregistration has a positive impact on PCI results.

支架植入期间的光学相干断层扫描 (OCT)-血管造影配准可能有助于避免地理不匹配和不完整的病灶覆盖。支架边缘未经处理的富含脂质的斑块与随后的支架边缘再狭窄有关。本研究旨在比较 OCT 引导下经皮冠状动脉介入治疗 (PCI) 与 OCT 血管造影联合配准在支架边缘未经治疗的富含脂质斑块的频率。我们调查了 398 名接受 OCT 引导的支架植入术的患者（共配准组中n  = 198，n = 200 在无配准组）。在 PCI 后的 OCT 中，未处理的脂质斑块通过 5 毫米支架边缘段中的最大脂质弧 > 180° 来识别。联合注册组和未联合注册组的 PCI 靶向病变特征和支架长度没有差异。联合配准组近端或远端支架边缘段未经处理的富含脂质斑块的频率显着低于未联合配准组（16% vs. 26%，P  = 0.015）。支架边缘剥离（5% vs. 6%，P  = 0.516）和未治疗狭窄（2% vs. 3%，P = 0.724) 较低，两组之间没有显着差异。在 OCT 引导的 PCI 中，使用 OCT 血管造影配准与支架边缘未经治疗的富含脂质斑块的频率降低有关。OCT 血管造影配准对 PCI 结果有积极影响。