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Trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in Parkinson disease.
PLOS Biology ( IF 9.8 ) Pub Date : 2021-07-20 , DOI: 10.1371/journal.pbio.3001331
Santhanasabapathy Rajasekaran 1 , Stephan N Witt 1
Affiliation  

In Parkinson disease (PD), Lewy bodies (LBs) form in the gut or nose and spread into the midbrain. A study in this issue indicates that the spread is due to lysosomes "infected" with prion-like alpha-synuclein (α-syn) transmitting from cell to cell via tunneling nanotubes (TNTs).

中文翻译:

特洛伊木马和隧道纳米管使 α-突触核蛋白病理学在帕金森病中传播。

在帕金森病 (PD) 中,路易体 (LB) 在​​肠道或鼻子中形成并扩散到中脑。本期的一项研究表明,这种传播是由于溶酶体“感染”了朊病毒样 α-突触核蛋白 (α-syn),通过隧道纳米管 (TNT) 在细胞之间传播。
更新日期:2021-07-20
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