Objective

To characterize national outcomes of oocyte thaw (OT) cycles.

Design

Retrospective descriptive study.

Setting

All autologous OT cycles reported to the Society of Assisted Reproductive Technology Clinic Outcome Reporting System from 2012 to 2018.

Patient(s)

All women undergoing OT cycles in the United States.

Intervention(s)

None.

Main Outcome Measure(s)

Absolute numbers of oocyte cryopreservation (OC) and OT cycles over time. Among OT cycles, patient and cycle characteristics, the ratio of the total number of oocytes thawed to the number of live births by maternal age at the time of cryopreservation (ATOC), and outcomes including pregnancy, miscarriage, live birth, and good perinatal outcome (GPO) by age ATOC.

Result(s)

From 2012 to 2018, 54,675 OC and 6,413 OT cycles were performed; the absolute numbers increased from 2,719 to 13,824 and from 348 to 1,810, respectively. The ratio of the total number of oocytes thawed to the number of live births increased significantly with increasing age ATOC, from 41.4 (age <35 years) to 122.4 (age >41 years). Among OT cycles resulting in embryo transfer, the live birth rate decreased with increasing age ATOC from 42.8% (age <35 years) to 10.8% (age >42 years). The live birth rate was higher when calculated per transfer (42.8% in women aged <35 years ATOC) rather than per thaw cycle (31.5% in women aged <35 years ATOC) because of the number of patients with no transfer. Among 1,124 cycles resulting in pregnancy, the chance of a GPO was highest among women aged <35 years ATOC (65.8%) and decreased as age at ATOC increased.

Conclusion(s)

Among reported OT cycles, the rates of pregnancy and live birth decreased as age ATOC increased. The number of oocytes thawed to achieve one live birth increased significantly with increasing age ATOC. In addition, among the resulting pregnancies, the rate of GPO decreased as age ATOC increased.

中文翻译：

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冷冻卵子：国家自体卵母细胞解冻结果

客观的

表征卵母细胞解冻 (OT) 周期的国家结果。

设计

回顾性描述性研究。

环境

2012 年至 2018 年向辅助生殖技术协会临床结果报告系统报告的所有自体 OT 周期。

耐心）

所有在美国接受 OT 周期的女性。

干预措施

没有任何。

主要观察指标）

随着时间的推移，卵母细胞冷冻保存 (OC) 和 OT 周期的绝对数量。在 OT 周期、患者和周期特征中，冷冻保存 (ATOC) 时按母亲年龄分列的解冻卵母细胞总数与活产数的比率，以及包括妊娠、流产、活产和良好围产期结局在内的结局(GPO) 按年龄 ATOC。

结果）

2012年至2018年，进行了54,675次OC和6,413次OT循环；绝对人数分别从 2,719 人增加到 13,824 人，从 348 人增加到 1,810 人。随着ATOC年龄的增加，解冻卵母细胞总数与活产儿数的比率显着增加，从41.4（年龄<35岁）到122.4（年龄>41岁）。在导致胚胎移植的 OT 周期中，活产率随着年龄 ATOC 的增加而降低，从 42.8%（年龄 <35 岁）到 10.8%（年龄 >42 岁）。由于没有转移的患者数量，按每次转移计算的活产率更高（<35 岁 ATOC 女性为 42.8%）而不是每个解冻周期（<35 岁 ATOC 女性为 31.5%）。在导致怀孕的 1,124 个周期中，年龄小于 35 岁 ATOC 的女性发生 GPO 的几率最高 (65.

结论

在报告的 OT 周期中，妊娠率和活产率随着年龄 ATOC 的增加而降低。随着 ATOC 年龄的增加，解冻获得 1 个活产的卵母细胞数量显着增加。此外，在由此产生的妊娠中，随着年龄 ATOC 的增加，GPO 的发生率下降。