Objectives

This trial aimed to determine the feasibility of recruitment, retention, adherence, and safety of a resistance training (RT) intervention to skeletal muscle failure in both frail and non-frail older adults.

Design

An 8-week randomised feasibility trial.

Setting and participants

Older adults, with and without frailty, recruited from both clinics and community.

Methods

Recruitment was based on the number of participants enrolled from those provided with a Patient Information Sheet (PIS). Retention was based on the number of participants who completed the trial. Adherence was based on the number of RT sessions attended out of 16. Outcomes included frailty (Fried criteria), muscle strength (maximal voluntary contraction), functional abilities (Short Physical Performance battery), quality of life (EQ-5D-5L), activities of daily living (LIADL) and safety (diary).

Results

Recruitment target (n = 60) was achieved within 15 months, 58 were randomised to high (n = 30) or low repetition-load (n = 28) groups. Mean age of participants was 72 years (range 65–93). Adherence and retention rate for the RT intervention was ≥70%. There was one serious adverse experience due to the RT intervention. There were no differences (P > 0.05) in effects of RT on outcome variables between low and high repetition-load groups.

Conclusions and implications

Recruitment of frail people was challenging. Older adults performing supervised RT to skeletal muscle failure was feasible and safe, with appropriate caution, and the repetition-load did not appear to influence its efficacy. Future research into the effectiveness of this simplified model of RT is warranted.

中文翻译：

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体弱和健康老年人不同负荷下的抗阻运动训练：一项随机可行性试验

目标

该试验旨在确定抗阻训练 (RT) 干预对体弱和非虚弱老年人骨骼肌衰竭的募集、保留、依从性和安全性的可行性。

设计

一项为期 8 周的随机可行性试验。

设置和参与者

从诊所和社区招募的老年人，无论是否虚弱。

方法

招募基于从提供患者信息表 (PIS) 的参与者中招募的参与者数量。保留是基于完成试验的参与者人数。依从性是基于参加的 16 次 RT 课程的数量。 结果包括虚弱（弗里德标准）、肌肉力量（最大随意收缩）、功能能力（短物理性能电池）、生活质量 (EQ-5D-5L)、日常生活活动（LIADL）和安全（日记）。

结果

 在 15 个月内实现了招募目标 ( n = 60)，其中 58 人被随机分配到高 ( n  = 30) 或低重复负荷 ( n  = 28) 组。参与者的平均年龄为 72 岁（范围 65-93）。放疗干预的依从性和保留率≥70%。由于 RT 干预，有一次严重的不良经历。 RT 对低重复负荷组和高重复负荷组的结果变量的影响没有差异 ( P > 0.05)。

结论和影响

招募体弱者具有挑战性。老年人对骨骼肌衰竭进行有监督的放疗是可行和安全的，适当谨慎，重复负荷似乎不会影响其疗效。有必要进一步研究这种简化的 RT 模型的有效性。