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Increased Nectin-4 levels in chronic ketamine abusers and the relationship with lower urinary tract symptoms
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2021-07-22 , DOI: 10.1016/j.etap.2021.103714
Hu-Ming Chang , Po-Yu Chen , Chiu-Ping Fang , Tung-Hsia Liu , Chun-Te Wu , Yu-Chao Hsu , Hsiang-Wei Kuo , Yu-Li Liu , Ming-Chyi Huang

Persistent ketamine use causes susceptibility to addiction and bladder toxicity. We examined the association of lower urinary tract symptoms and levels of Nectin-4, a member of the cell adhesion molecules that is essential for maintaining the urothelium barrier in chronic ketamine abusers. We measured the plasma levels of Nectin-4 in 88 patients with ketamine dependence and 69 controls. Patients with ketamine dependence were assessed for ketamine use variables, psychological symptoms, and lower urinary tract symptoms. We found Nectin-4 levels were increased in ketamine-dependent patients compared to the controls (p < 0.0001). Patients with urinary tract symptoms exhibited lower Nectin-4 levels than those without (p = 0.021). Our results suggest an up-regulation of Nectin-4 following chronic and heavy ketamine use. Patients with ketamine dependence with a compromised upregulation of Nectin-4 are likely to have more severe urinary tract symptoms. The mechanisms underlying the involvement of Nectin-4 in ketamine addiction and bladder toxicity warrant future investigation.



中文翻译:

慢性氯胺酮滥用者的 Nectin-4 水平升高及其与下尿路症状的关系

持续使用氯胺酮会导致对成瘾和膀胱毒性的易感性。我们检查了下尿路症状与 Nectin-4 水平的关联,Nectin-4 是细胞粘附分子的成员,对于维持慢性氯胺酮滥用者的尿路上皮屏障至关重要。我们测量了 88 名氯胺酮依赖患者和 69 名对照患者的 Nectin-4 血浆水平。对氯胺酮依赖患者的氯胺酮使用变量、心理症状和下尿路症状进行了评估。我们发现与对照组相比,氯胺酮依赖患者的 Nectin-4 水平升高(p < 0.0001)。有尿路症状的患者的 Nectin-4 水平低于没有症状的患者(p= 0.021)。我们的结果表明,在长期和大量使用氯胺酮后,Nectin-4 上调。Nectin-4 上调受损的氯胺酮依赖患者可能会出现更严重的尿路症状。Nectin-4 参与氯胺酮成瘾和膀胱毒性的潜在机制值得进一步研究。

更新日期:2021-07-24
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