Endometrial function is essential for embryo implantation and pregnancy, but managing endometrial thickness that is too thin to support pregnancy or an endometrium of compromised functionality due to intrauterine adhesions is an ongoing challenge in reproductive medicine. Here, we review current and emerging therapeutic and experimental options for endometrial regeneration with a focus on animal models used to study solutions for Asherman's syndrome and endometrial atrophy, which both involve a damaged endometrium. A review of existing literature was performed that confirmed the lack of consensus on endometrial therapeutic options, though promising new alternatives have emerged in recent years (platelet-rich plasma, exosomes derived from stem cells, bioengineering-based techniques, endometrial organoids, among others). In the future, basic research using established experimental models of endometrial pathologies (combined with new high-tech solutions) and human clinical trials with large population sizes are needed to evaluate these emerging and new endometrial therapies.

中文翻译：

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管理阿舍曼综合征和子宫内膜萎缩的策略：从经典实验模型到新的生物工程方法

子宫内膜功能对于胚胎植入和妊娠至关重要，但管理因太薄而无法支持妊娠的子宫内膜或因宫腔粘连而导致功能受损的子宫内膜是生殖医学中的一项持续挑战。在这里，我们回顾了当前和新兴的子宫内膜再生治疗和实验选择，重点关注用于研究 Asherman 综合征和子宫内膜萎缩解决方案的动物模型，这两者都涉及受损的子宫内膜。对现有文献的回顾证实了对子宫内膜治疗方案缺乏共识，尽管近年来出现了有希望的新替代方案（富含血小板的血浆、来自干细胞的外泌体、基于生物工程的技术、子宫内膜类器官等） . 将来，