Lung cancer as one of the commonest invasive malignancies is featured by high morbidity and mortality, wherein lung adenocarcinoma (LUAD) is the most prevalent subtype. Accumulating evidence exhibited that microRNAs are involved in LUAD occurrence and progression. In this study, miR-182-5p was observed to increase in both LUAD tissue and cell lines. Overexpression of miR-182-5p could prominently facilitate cell proliferation, migration, and invasion in LUAD. Through bioinformatics analysis, STARD13 was theorized as the target gene of miR-182-5p, which was lowly expressed in LUAD. Further molecular experiments manifested that miR-182-5p bound to the 3-untranslated region of STARD13, and there was an inverse correlation between STARD13 and miR-182-5p in LUAD. Rescue experiments demonstrated that silencing STARD13 conspicuously restored the inhibitory effect of decreased miR-182-5p on cell proliferation, migration, and invasion in LUAD. Together, our findings revealed novel roles of the miR-182-5p/STARD13 axis in LUAD progression.

中文翻译：

---

miR-182-5p 通过与 STARD13 结合作为肺腺癌的癌基因

肺癌作为最常见的侵袭性恶性肿瘤之一，具有较高的发病率和死亡率，其中肺腺癌（LUAD）是最常见的亚型。越来越多的证据表明 microRNA 参与 LUAD 的发生和进展。在这项研究中，观察到 miR-182-5p 在 LUAD 组织和细胞系中均有所增加。miR-182-5p 的过表达可以显着促进 LUAD 中的细胞增殖、迁移和侵袭。通过生物信息学分析，推测STARD13是LUAD中低表达的miR-182-5p的靶基因。进一步的分子实验表明，miR-182-5p与STARD13的3-非翻译区结合，并且LUAD中STARD13与miR-182-5p之间存在负相关。拯救实验表明，沉默 STARD13 显着恢复了 miR-182-5p 减少对 LUAD 细胞增殖、迁移和侵袭的抑制作用。总之，我们的研究结果揭示了 miR-182-5p/STARD13 轴在 LUAD 进展中的新作用。