Transdermal therapeutic systems (TTS) based on pressure-sensitive adhesives (PSAs) allow for the application of pharmaceutical substances via diffusion through the skin. The rheological performance of PSA is largely investigated within small amplitude oscillatory shear (typically up to 1 %), although the skin motions exceed strains beyond 40 %. In this paper, amine-compatible (AC) and non-amine-compatible (NAC) silicone-based PSA compounds differing in the resin content were subjected to strain amplitude sweeps in a twin drive rheometer. Carreau-Yasuda-like fitting of storage and loss moduli curves intercepts the substantial effect of resin content on both compounds; up to four times higher, moduli of AC compounds were determined in SAOS, and their higher molecular mass combined with enhanced interactions contributed to an earlier transition to the nonlinear viscoelastic region. In the nonlinear range, elastic and viscous properties are affected by strains in a different manner with the trend favorable for the PSA application as TTS. The third relative higher harmonic from Fourier transformation I_3/1 as well as intra-cycle strain stiffening and shear thickening ratios provide information relevant for an optimization of PSA subjected to large deformations.

基于压敏粘合剂 (PSA) 的透皮治疗系统 (TTS) 允许通过皮肤扩散来应用药物。PSA 的流变性能主要在小振幅振荡剪切（通常高达 1%）内进行研究，尽管皮肤运动超过应变超过 40%。在本文中，在双驱动流变仪中对树脂含量不同的胺相容 (AC) 和非胺相容 (NAC) 有机硅基 PSA 化合物进行了应变振幅扫描。Carreau-Yasuda 类存储和损耗模量曲线拟合截断了树脂含量对两种化合物的实质性影响；高达四倍，在 SAOS 中测定了 AC 化合物的模量，它们的较高分子量与增强的相互作用相结合，有助于更早地过渡到非线性粘弹性区域。在非线性范围内，弹性和粘性特性以不同的方式受应变影响，趋势有利于 PSA 应用作为 TTS。傅立叶变换的三次相对高次谐波I _3/1以及循环内应变硬化和剪切增厚比提供了与经受大变形的 PSA 优化相关的信息。