Abstract

One new cycloartane-type triterpenoid, named macrobidoupoic acid A (as an C-24 epimeric mixture, 4a, 4 b), together with three known ones (1-3), were clarified by different chromatography from the M. bidoupensis whole plants. Triterpenoids (1, 3 & 4) were detected for the first time from the Macrosolen genus. Chemical structures of them were illuminated using HR-ESI-MS, and NMR (1 D & 2 D) assessments. The cytotoxic properties of triterpenoids (3 & 4) were examined against two human cancer cell lines (A549, and RD) by MTT assay. As results shown, triterpenoids (3 & 4) possessed moderate cytotoxic activity against A549 and RD cancer cells (IC₅₀ ranged from 5.44 to 39.52 μM).

摘要

一种新的环阿坦型三萜类化合物，命名为大环双二辛酸 A（作为 C-24 差向异构体混合物，4a，4b），连同三种已知的三萜化合物（1-3），通过不同的色谱法从M.bidoupensis整个植物中得到澄清。首次从Macrosolen属中检测到三萜类化合物（1、3和4 ）。使用 HR-ESI-MS 和 NMR (1 D & 2 D) 评估阐明了它们的化学结构。通过 MTT 法检测了三萜类化合物 ( 3和4 ) 对两种人类癌细胞系（A549 和 RD）的细胞毒性。结果表明，三萜类化合物（3& 4 ) 对 A549 和 RD 癌细胞具有中等的细胞毒活性（IC ₅₀范围为 5.44 至 39.52 μM）。