ABSTRACT

Introduction

Examination of disease biomarkers mostly performed on crude materials, such as serum, meets some obstacles, resulting from sample complexity and the wide range of concentrations and sizes of the components. Techniques currently used in clinical diagnostics are usually time-consuming and expensive. The more sensitive and portable devices are needed for early diagnostics. Chemical sensors are devices that convert chemical information into parameters suitable for fast and precise processing and measurement.

Area covered

We review the use of biosensors and their possible application in early diagnostics of some diseases like cancer or viral infections. We focus on different types of biorecognition and some technical modifications, lowering the limit of detection potentially attractive to medical practitioners.

Expert opinion

Among the new diagnostic strategies, the use of biosensors is of increasing interest. In these techniques, the capture ligand interacts with the analyte of interest. Measuring interactions between partners in real time by surface plasmon resonance yields valuable information about kinetics and affinity in a short time and without labels. Importantly, the tendency in such techniques is to make biosensor devices smaller and the test results apparent with the naked eye, so they can be used in point-of-care medicine.

中文翻译：

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选定的生物传感器技术在临床诊断中的应用

摘要

介绍

疾病生物标志物的检查主要在血清等原材料上进行，但由于样品复杂性以及成分的浓度和大小范围广泛，因此遇到了一些障碍。目前用于临床诊断的技术通常耗时且昂贵。早期诊断需要更灵敏和便携的设备。化学传感器是将化学信息转换为适合快速和精确处理和测量的参数的设备。

覆盖面积

我们回顾了生物传感器的使用及其在癌症或病毒感染等某些疾病的早期诊断中的可能应用。我们专注于不同类型的生物识别和一些技术修改，降低对医生可能具有吸引力的检测极限。

专家意见

在新的诊断策略中，生物传感器的使用越来越受到关注。在这些技术中，捕获配体与目标分析物相互作用。通过表面等离子共振实时测量合作伙伴之间的相互作用，可以在短时间内获得有关动力学和亲和力的有价值信息，并且无需标记。重要的是，此类技术的趋势是使生物传感器设备更小，并且肉眼可以看到测试结果，因此它们可以用于即时医疗。