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Phosphine-Free Manganese(II)-Catalyst Enables Acceptorless Dehydrogenative Coupling of Alcohols with Indoles
Advanced Synthesis & Catalysis ( IF 5.4 ) Pub Date : 2021-07-21 , DOI: 10.1002/adsc.202100621
Vinita Yadav 1, 2 , Ekambaram Balaraman 3 , Santosh B. Mhaske 1, 2
Affiliation  

Herein, an air-stable, molecularly defined NNN−Mn(II) pincer complex catalyzed acceptorless dehydrogenative coupling of alcohols with indoles is reported. A wide variety of symmetrical and unsymmetrical bis(indolyl)methane derivatives as well as some structurally important products such as Vibrindole A, Turbomycin B alkaloid, Antileukemic, and Anticancer agents were synthesized. Mechanistic studies illustrate the importance of the NH moiety in the complex and the crucial role of metal-ligand cooperation during catalysis.

中文翻译:

无膦锰 (II) 催化剂使醇与吲哚的无受体脱氢偶联成为可能

本文报道了一种空气稳定的、分子定义的 NNN-Mn(II) 钳形复合物催化醇与吲哚的无受体脱氢偶联。合成了多种对称和非对称双(吲哚基)甲烷衍生物以及一些结构上重要的产品,如 Vibrindole A、Turbomycin B 生物碱、抗白血病和抗癌剂。机理研究说明了 NH 部分在配合物中的重要性以及金属-配体合作在催化过程中的关键作用。
更新日期:2021-09-21
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