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Neuropsychological Profiles of Patients with Progressive Apraxia of Speech and Aphasia
Journal of the International Neuropsychological Society ( IF 2.6 ) Pub Date : 2021-07-22 , DOI: 10.1017/s1355617721000692
Angelina J Polsinelli 1 , Mary M Machulda 2 , Peter R Martin 3 , Joseph R Duffy 4 , Heather M Clark 4 , Alissa M Butts 5 , Hugo Botha 4 , Val J Lowe 6 , Jennifer L Whitwell 6 , Keith A Josephs 4 , Rene L Utianski 4
Affiliation  

Objective:

To characterize and compare the neuropsychological profiles of patients with primary progressive apraxia of speech (PPAOS) and apraxia of speech with progressive agrammatic aphasia (AOS-PAA).

Method:

Thirty-nine patients with PPAOS and 49 patients with AOS-PAA underwent formal neurological, speech, language, and neuropsychological evaluations. Cognitive domains assessed included immediate and delayed episodic memory (Wechsler Memory Scale-Third edition; Logical Memory; Visual Reproduction; Rey Auditory Verbal Learning Test), processing speed (Trail Making Test A), executive functioning (Trail Making Test B; Delis-Kaplan Executive Functioning Scale – Sorting), and visuospatial ability (Rey-Osterrieth Complex Figure copy).

Results:

The PPAOS patients were cognitively average or higher in the domains of immediate and delayed episodic memory, processing speed, executive functioning, and visuospatial ability. Patients with AOS-PAA performed more poorly on tests of immediate and delayed episodic memory and executive functioning compared to those with PPAOS. For every 1 unit increase in aphasia severity (e.g. mild to moderate), performance declined by 1/3 to 1/2 a standard deviation depending on cognitive domain. The degree of decline was stronger within the more verbally mediated domains, but was also notable in less verbally mediated domains.

Conclusion:

The study provides neuropsychological evidence further supporting the distinction of PPAOS from primary progressive aphasia and should be used to inform future diagnostic criteria. More immediately, it informs prognostication and treatment planning.



中文翻译:

进行性言语失用症和失语症患者的神经心理学概况

客观的:

描述和比较原发性进行性言语失用症 (PPAOS) 和言语失用症伴进行性语法失语症 (AOS-PAA) 患者的神经心理学特征。

方法:

39 名 PPAOS 患者和 49 名 AOS-PAA 患者接受了正式的神经学、言语、语言和神经心理学评估。评估的认知领域包括即时和延迟情景记忆(Wechsler 记忆量表-第三版;逻辑记忆;视觉再现;Rey 听觉语言学习测试)、处理速度(Trail Making 测试 A)、执行功能(Trail Making 测试 B;Delis-Kaplan执行功能量表 - 排序)和视觉空间能力(Rey-Osterrieth Complex Figure copy)。

结果:

PPAOS 患者在即时和延迟情景记忆、处理速度、执行功能和视觉空间能力方面的认知水平平均或更高。与 PPAOS 患者相比,AOS-PAA 患者在即时和延迟情景记忆和执行功能测试中表现更差。失语症严重程度(例如轻度到中度)每增加 1 个单位,表现就会下降 1/3 到 1/2 个标准偏差,具体取决于认知领域。在语言介导较多的领域中,下降程度更强,但在语言介导较少的领域中也很明显。

结论:

该研究提供了神经心理学证据,进一步支持 PPAOS 与原发性进行性失语症的区别,并应用于为未来的诊断标准提供信息。更直接地,它通知预后和治疗计划。

更新日期:2021-07-22
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