A series of nylon-like oligomers was synthesized, which consisted of alternating cyclic 1,2-diamine and 1,2-dicarboxylic acid building blocks with a five-membered ring constraint. The nylon 2 4 oligomers are symmetric and display helical structures similar to the β-peptide 12-helix with intramolecular 12-membered ring hydrogen bonds. The cyclopentane moiety allows each building block to promote 12-helical folding. In addition, a tartaric acid derivative with the acetonide moiety increases the solubility of oligomers in common organic solvents and promotes helical folding.

中文翻译：

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由含有五元环约束的 1,2-二胺和 1,2-二羧酸结构单元组成的类尼龙低聚物的螺旋结构

合成了一系列类似尼龙的低聚物，由交替的环状 1,2-二胺和 1,2-二羧酸结构单元组成，具有五元环约束。尼龙 2 4 低聚物是对称的，并显示出类似于具有分子内 12 元环氢键的 β-肽 12-螺旋的螺旋结构。环戊烷部分允许每个结构单元促进 12 螺旋折叠。此外，具有丙酮化物部分的酒石酸衍生物增加了低聚物在普通有机溶剂中的溶解度并促进了螺旋折叠。