This case report presents a 33-year-old woman with premature ventricular contractions (PVCs). Her genetic testing was positive for KCNJ2 missense mutation at chr17:68171832;NM_000891.2. This mutation was compatible with Andersen-Tawil syndrome. We made an electrophysiological study to determine origin of PVCs however at endocardial mapping there was not any focus of PVC and at epicardial mapping we ablated low voltage areas in the inferior segments of both ventricles. She was discharged with flecainide and metoprolol therapy. After 3 months, her PVC burden was significantly decreased at Holter monitoring.

中文翻译：

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射频导管消融失败和氟卡尼成功抑制 Andersen-Tawil 综合征的室性早搏：病例报告

本病例报告介绍了一名患有室性早搏 (PVC) 的 33 岁女性。她的基因检测结果显示 chr17:68171832;NM_000891.2 处的 KCNJ2 错义突变呈阳性。这种突变与 Andersen-Tawil 综合征相容。我们进行了电生理学研究以确定 PVC 的起源，但是在心内膜标测中没有任何 PVC 焦点，在心外膜标测中我们消融了两个心室下段的低电压区域。她出院后接受氟卡尼和美托洛尔治疗。3 个月后，她的 PVC 负荷在 Holter 监测中显着降低。