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TMAO reductase, a biomarker for gut permeability defect induced inflammation, in mouse model of chronic kidney disease and dextran sulfate solution-induced mucositis.
Asian Pacific Journal of Allergy and Immunology ( IF 5 ) Pub Date : 2021-07-21 , DOI: 10.12932/ap-100321-1084
Sompong Boonhai 1 , Kanthika Bootdee 2 , Wilasinee Saisorn 2 , Kullaya Takkavatakarn 3 , Patita Sitticharoenchai 4 , Somkanya Tungsanga 3 , Khajohn Tiranathanagul 3 , Asada Leelahavanichkul 2, 3, 5
Affiliation  

The excretion of trimethylamine N-oxide (TMAO) (uremic toxin) into the intestine might be enhanced, due to the limited renal elimination in chronic kidney disease (CKD), possibly induced TMAO reductase (a TMAO-neutralizing enzyme) in gut bacteria. Detection of TMAO reductase in serum could be used as a biomarker of gut permeability defect.

中文翻译:

TMAO 还原酶是慢性肾病和硫酸葡聚糖溶液诱导的粘膜炎小鼠模型中肠道通透性缺陷诱导炎症的生物标志物。

由于慢性肾病 (CKD) 中肾清除有限,三甲胺 N-氧化物 (TMAO)(尿毒症毒素)排泄到肠道可能会增强,可能会诱导肠道细菌中的 TMAO 还原酶(一种 TMAO 中和酶)。检测血清中TMAO还原酶可作为肠道通透性缺陷的生物标志物。
更新日期:2021-07-21
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