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Elevated levels of cortisol, brain-derived neurotropic factor and tissue plasminogen activator in male children with autism spectrum disorder
Autism Research ( IF 4.7 ) Pub Date : 2021-07-22 , DOI: 10.1002/aur.2582
Hasan Bozkurt 1 , Şeref Şimşek 2 , Serkan Şahin 1
Affiliation  

Several studies demonstrated biological effects of cortisol, brain-derived neurotrophic factor (BDNF) and tissue plasminogen activator (tPA) on human metabolism and central nervous system. Our study investigated the serum levels of tPA along with BDNF and cortisol in children with autism spectrum disorder (ASD). Thirty three male children with ASD ranging in age from 2 to 15 years were selected for the study group and 27 age-matched healthy male children were selected for the control group. The ASD severity was determined by the score on the Autism Behavior Checklist (ABC). The mean cortisol levels for the study group and the control group were 79.1 ± 30.2 ng/ml and 60.0 ± 25.1 ng/ml, respectively. The mean BDNF levels for the study group and the control group were 5.9 ± 2.8 ng/ml and 3.7 ± 1.8 ng/ml, respectively. The mean tPA levels for the study group and the control group were 32.9 ± 18.5 ng/ml and 25.5 ± 15.1 ng/ml, respectively. Cortisol, BDNF and tPA levels were significantly higher in the study group compared to the control group (p < 0.001). There was no statistically significant effect in terms of age, ABC total and subscale scores on serum cortisol, BDNF and tPA levels in the study group (p > 0.05). It may be suggested that elevations may indicate a role in the pathogenesis of ASD or it may be the case that ASD may alter the levels or pathways of these metabolic factors.

中文翻译:

自闭症谱系障碍男童皮质醇、脑源性神经营养因子和组织纤溶酶原激活剂水平升高

几项研究证明了皮质醇、脑源性神经营养因子 (BDNF) 和组织纤溶酶原激活剂 (tPA) 对人体代谢和中枢神经系统的生物学影响。我们的研究调查了自闭症谱系障碍 (ASD) 儿童的 tPA 以及 BDNF 和皮质醇的血清水平。研究组选取 33 名年龄在 2 至 15 岁之间的 ASD 男性儿童,选取 27 名年龄匹配的健康男性儿童作为对照组。ASD 严重程度由自闭症行为检查表 (ABC) 上的分数确定。研究组和对照组的平均皮质醇水平分别为 79.1 ± 30.2 ng/ml 和 60.0 ± 25.1 ng/ml。研究组和对照组的平均 BDNF 水平分别为 5.9 ± 2.8 ng/ml 和 3.7 ± 1.8 ng/ml。研究组和对照组的平均 tPA 水平分别为 32.9 ± 18.5 ng/ml 和 25.5 ± 15.1 ng/ml。与对照组相比,研究组的皮质醇、BDNF 和 tPA 水平显着升高(p  < 0.001)。研究组年龄、ABC总分和分量表评分对血清皮质醇、BDNF和tPA水平的影响均无统计学意义(p  >0.05)。可能表明升高可能表明在 ASD 的发病机制中起作用,或者 ASD 可能会改变这些代谢因子的水平或途径。
更新日期:2021-07-22
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