JNK pathway-associated phosphatase (JKAP) is previously reported to regulate immune/inflammatory process via T-cell signaling, and closely involves in neurological diseases, while its implication in Parkinson's disease (PD) is unknown. Therefore, this study aimed to investigate the correlation of JKAP with Th1/Th2/Th17 cells and their clinical roles in PD patients, and then further explore the effect of JKAP on regulating CD4⁺ T-cell differentiation in PD.

中文翻译：

---

JKAP 与帕金森病中的疾病风险、严重程度以及 Th1 和 Th17 分化有关

JNK 通路相关磷酸酶 (JKAP) 先前被报道通过 T 细胞信号传导调节免疫/炎症过程，并与神经系统疾病密切相关，而其在帕金森病 (PD) 中的影响尚不清楚。因此，本研究旨在探讨 JKAP 与 Th1/Th2/Th17 细胞的相关性及其在 PD 患者中的临床作用，进而进一步探讨 JKAP 在调节 PD 中 CD4 ⁺ T 细胞分化的作用。