The structure of complex cis-Pd(HL^Me)Cl₂ was studied both in solution and in solid state using multinuclear (¹H, ¹³C, ¹⁵N) NMR spectroscopy and X-ray structural analysis. Complex was evaluated for cytotoxic activity. Thus, the results showed that cis-Pd(HL^Me)Cl₂ has a pronounced cytotoxicity toward human leukemic lymphoblast’s CCRF-CEM and cervix adenocarcinoma HeLa cells. Moreover, it was found that cis-Pd(HL^Me)Cl₂ is more toxic than cisplatin: its IC₅₀ value at 24 h incubation was lower by more than an order for CCRF-CEM cells and by three orders for HeLa cells as compared with cisplatin IC₅₀. Depending on the concentration, cis-Pd(HL^Me)Cl₂ is accelerated or slowed hemolysis of erythrocytes. Observed differential biological effects of cis-Pd(HL^Me)Cl₂ suggest the dependence of the agent’s interactions with cells on the molecular structure of palladium ligand and the cell type.

复杂的结构顺式-钯（HL^我）氯₂使用多核在溶液中和在固体状态进行了研究（¹ H，¹³ C，¹⁵ N）NMR光谱和X射线结构分析。评估复合物的细胞毒活性。因此，结果表明cis - Pd(HL ^Me )Cl ₂对人白血病淋巴母细胞的CCRF-CEM和宫颈腺癌HeLa细胞具有明显的细胞毒性。此外，人们发现，顺式-钯（HL^我）氯₂是更毒性比顺铂：其IC ₅₀与顺铂 IC ₅₀相比，CCRF-CEM 细胞在 24 小时孵育时的 γ 值低一个数量级以上，HeLa 细胞低三个数量级。根据浓度，cis- Pd(HL ^Me )Cl ₂加速或减缓红细胞的溶血。观察到的cis - Pd(HL ^Me )Cl _{2 的}不同生物学效应表明，该试剂与细胞的相互作用依赖于钯配体的分子结构和细胞类型。