Neonicotinoids and heavy metals pollution exist simultaneously in agro ecosystem. However, little is known about their combined ecotoxicological effects on non-target crop plants. We have selected imidacloprid (IMI) and cadmium (Cd), applied alone and in combination, to evaluate their effect on growth, physiological and biochemical parameters of tomato. Results showed that the single application of contaminants (IMI and/or Cd) adversely affected both the growth and chlorophyll pigment, and Cd alone application was more phytotoxic than IMI. However, their combined action aggravated the inhibitory effect and indicate a synergistic effect, but it exerted antagonistic effects on chlorophyll pigment inhibition compared with IMI and Cd alone treatments. Both chemicals increased hydrogen peroxide level and generated lipid peroxidation, and the co-contamination exacerbates oxidative stress by their synergistic effect. Those results implicate that disturbance of cellular redox status is the plausible mechanism for IMI and Cd induced toxicity. In conclusion, the single or combined IMI and Cd cause negative effects on tomatoes.

新烟碱类和重金属污染在农业生态系统中同时存在。然而，关于它们对非目标作物植物的综合生态毒理学影响知之甚少。我们选择了吡虫啉 (IMI) 和镉 (Cd)，单独使用和组合使用，以评估它们对番茄生长、生理和生化参数的影响。结果表明，单独施用污染物（IMI 和/或 Cd）对生长和叶绿素色素都有不利影响，单独施用 Cd 比 IMI 更具植物毒性。然而，它们的联合作用加重了抑制作用并表明了协同作用，但与单独使用 IMI 和 Cd 相比，它对叶绿素色素抑制产生了拮抗作用。这两种化学物质都会增加过氧化氢水平并产生脂质过氧化作用，并且共污染通过它们的协同作用加剧了氧化应激。这些结果暗示细胞氧化还原状态的干扰是 IMI 和 Cd 诱导毒性的合理机制。总之，单一或组合的 IMI 和 Cd 会对西红柿产生负面影响。