Arginine-functionalized amino flowered mesoporous silica (A-FMS-Arg) nanoparticles are fabricated via the amidation reaction, and taken as efficient sorbent for refined extraction of heparin. Attributed by the multiple H-bond interaction between the sulfate group of heparin and the guanidine group of Arginine, A-FMS-Arg nanoparticles exhibit favorable adsorption selectivity towards heparin. The three-dimensional flowered structure provides A-FMS-Arg with abundant adsorption sites, and the adsorption capacity is high to 173.71 mg/g. 1HNMR assay indicate that A-FMS-Arg nanoparticles can selectively adsorb heparin from the mixture of heparin/chondroitin, and the practicability of A-FMS-Arg is well demonstrated by the efficient extraction of heparin from digested porcine intestinal mucosa.

通过酰胺化反应制备了精氨酸官能化氨基花介孔二氧化硅 (A-FMS-Arg) 纳米粒子，并将其作为高效吸附剂用于精制肝素。由于肝素的硫酸盐基团和精氨酸的胍基团之间的多重氢键相互作用，A-FMS-Arg 纳米颗粒对肝素表现出良好的吸附选择性。三维花状结构为A-FMS-Arg提供了丰富的吸附位点，吸附容量高达173.71 mg/g。1HNMR 分析表明，A-FMS-Arg 纳米颗粒可以从肝素/软骨素混合物中选择性吸附肝素，从消化的猪肠黏膜中有效提取肝素充分证明了 A-FMS-Arg 的实用性。