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Characterization of laryngeal motor neuron properties in the American bullfrog, Lithobates catesbieanus
Respiratory Physiology & Neurobiology ( IF 2.3 ) Pub Date : 2021-07-21 , DOI: 10.1016/j.resp.2021.103745
Tanya Zubov 1 , Sara Silika 1 , Saihari S Dukkipati 2 , Lynn K Hartzler 3 , Joseph M Santin 1
Affiliation  

Motor neurons represent the final output from the central respiratory network. American bullfrogs, Lithobates catesbieanus, have provided insight into development and plasticity of the breathing control system, yet cellular aspects of bullfrog motor neurons are not well-described. In this study, we characterized properties of laryngeal motor neurons that produce motor outflow to the glottal dilator, a muscle that gates airflow to the lungs of anurans. To this end, we measured several intrinsic membrane properties of labeled laryngeal motor neurons in brain slices. Using unsupervised clustering analyses, we identified two broad classes of motor neurons: those with high firing rates and strong adaptation (∼70 %), and those with lower firing rates and less adaptation (∼30 %). These results suggest that two neuronal cell types innervate the glottal dilator, roughly aligning with the composition of fast and slower twitch fibers of this muscle. In sum, these data reinforce the need to consider cell-type when assessing motor neuron function in the respiratory network.



中文翻译:

美国牛蛙 Lithobates catesbieanus 喉部运动神经元特性的表征

运动神经元代表中央呼吸网络的最终输出。美国牛蛙,Lithobates catesbieanus,提供了对呼吸控制系统的发展和可塑性的洞察,但牛蛙运动神经元的细胞方面没有得到很好的描述。在这项研究中,我们描述了喉部运动神经元的特性,这些神经元产生流向声门扩张器的运动流出,声门扩张器是一种控制气流进入无尾目动物肺部的肌肉。为此,我们测量了脑切片中标记的喉部运动神经元的几种内在膜特性。使用无监督聚类分析,我们确定了两大类运动神经元:具有高放电率和强适应性(~70%)的运动神经元,以及具有较低放电率和较少适应性(~30%)的运动神经元。这些结果表明,两种神经元细胞类型支配声门扩张器,大致与该肌肉的快肌和慢肌纤维的组成一致。总共,

更新日期:2021-07-30
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