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Biodegradable and conductive PVA/CNT nanofibrous membranes used in nerve conduit applications
Journal of Industrial Textiles ( IF 3.2 ) Pub Date : 2021-07-22 , DOI: 10.1177/15280837211032086
Jia-Ci Jhang, Jia-Horng Lin, Ching-Wen Lou, Yueh-Sheng Chen

The recovery of impaired peripheral nerves is often not as expected, which makes the development of nerve conduits trendy nowadays. To enable the neural messages effectively being delivered as well as to prevent the secondary damage during the removal of nerve conduits, the conductivity and biodegradability are two essential requirements for ideal nerve conduits. In this study, electrospinning is used to produce polyvinyl alcohol (PVA)/carbon nanotubes (CNT) electrospun films, after which the morphology analysis, electrical property, water contact angle, and biological characteristics of the membranes are investigated, thereby determining the optimal nerve conduits based on the employment of electrospinning, PVA, and CNT. The test results indicate that with 0.25 wt% of PVA, the electrospun films exhibit comparatively lower resistance of 25.3 ohm, good fibrous morphology with a diameter being 1 μm. In addition, the electrospun films are cytotoxicity-free and facilitate the growth of cells. It is observed in the MMT assay that after co-cultured with cells for three days, PVA/CNT electrospinning fibrous membranes exhibit a cellular viability that is 18.5 times greater than that of the control group on Day 1. According to all property evaluations, PVA/CNT electrospinning fibrous membranes are a qualified candidate for the use of nervous conduits.



中文翻译:

用于神经导管应用的可生物降解和导电的 PVA/CNT 纳米纤维膜

受损的周围神经的恢复往往不如预期,这使得神经导管的发展成为当今的趋势。为了使神经信息能够有效传递并防止在去除神经导管过程中产生二次损伤,导电性和生物降解性是理想神经导管的两个基本要求。本研究采用静电纺丝法制备聚乙烯醇 (PVA)/碳纳米管 (CNT) 静电纺丝薄膜,然后对膜的形态分析、电学性质、水接触角和生物学特性进行研究,从而确定最佳神经纤维。基于使用静电纺丝、PVA 和 CNT 的导管。测试结果表明,使用 0.25 wt% 的 PVA,电纺薄膜表现出相对较低的电阻,为 25.3 ohm,良好的纤维形态,直径为 1 μm。此外,静电纺丝薄膜无细胞毒性,促进细胞生长。在 MMT 实验中观察到,与细胞共培养 3 天后,PVA/CNT 静电纺丝纤维膜在第 1 天表现出的细胞活力是对照组的 18.5 倍。 根据所有性能评估,PVA /CNT 静电纺丝纤维膜是使用神经导管的合格候选材料。

更新日期:2021-07-22
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