Urinary tract infection (UTI) is regarded one of the most frequent bacterial infections in women. Accordingly, the aim of the current study was to determine the prevalence of extended-spectrum beta-lactamase (ESBL), as well as the degree of antimicrobial resistance among premenopausal (n = 44) and postmenopausal (n = 49) women suffering from uncomplicated UTI. Urinary samples (n = 93) collected from women with UTI were tested for their antimicrobial sensitivity and assessed for ESBL production by both phenotypic and genotypic methods. Phenotypically, the presence of ESBL was observed in 64 isolates, while polymerase chain reaction detected ESBL-encoding genes in 57 isolates. The CTX-M gene was the most predominant (51.6%), followed by TEM (46.2%), and the SHV gene (17.2%). Surprisingly, all ESBL-producing Escherichia coli isolates were multidrug-resistant (MDR). To the best of our knowledge, this is the first study conducted in Egypt showing significant correlation between ESBL production, multidrug resistance and menopausal state in women. The results demonstrate alarming signal for the dissemination of ESBL genes among uropathogenic E. coli that are MDR in Egypt.

尿路感染 (UTI) 被认为是女性最常见的细菌感染之一。因此，本研究的目的是确定超广谱 β-内酰胺酶 (ESBL) 的流行率，以及绝经前 ( n  = 44) 和绝经后 ( n  = 49) 患有无并发症的女性的抗菌素耐药性程度。尿路感染。尿样 ( n = 93) 从患有 UTI 的女性中收集的样本进行了抗菌敏感性测试，并通过表型和基因型方法评估了 ESBL 的产生。在表型上，在 64 个分离株中观察到 ESBL 的存在，而聚合酶链反应在 57 个分离株中检测到 ESBL 编码基因。CTX-M 基因最为显着（51.6%），其次是 TEM（46.2%）和 SHV 基因（17.2%）。令人惊讶的是，所有产 ESBL 的大肠杆菌分离株都具有多重耐药性 (MDR)。据我们所知，这是在埃及进行的第一项研究，显示 ESBL 产生、多药耐药性和女性更年期状态之间存在显着相关性。结果表明 ESBL 基因在泌尿致病性大肠杆菌中传播的警告信号 那是埃及的 MDR。