The increasing CO₂-concentrations in the atmosphere promote ocean acidification. Seawater chemistry changes interact with contaminants, such as illicit drugs in the coastal zones. This work evaluates impacts of pH decrease and crack-cocaine exposure on the commercial mussel Perna perna through biomarker responses (lysosomal membrane stability, lipid peroxidation, and DNA strand breaks). The organisms were exposed to different crack-cocaine concentrations (0.5, 5.0, and 50 μg L⁻¹) combined with different pH values (8.3, 8.0, 7.5, 7.0, 6.5, and 6.0) for 96 h. Crack-cocaine in the different acidification scenarios triggered cyto-genotoxicity, which affected the overall health of mussels exposed to cocaine environmentally relevant concentration. This study produced the first data on biomarker responses associated with CO₂-induced acidification and illicit drugs (crack-cocaine) in marine organisms.

大气中不断增加的 CO ₂浓度促进了海洋酸化。海水化学变化与污染物相互作用，例如沿海地区的非法药物。这项工作通过生物标志物反应（溶酶体膜稳定性、脂质过氧化和 DNA 链断裂）评估了 pH 值降低和可卡因暴露对商业贻贝Perna perna 的影响。生物体暴露于不同浓度的快克可卡因（0.5、5.0 和 50 μg L ^-1) 与不同的 pH 值（8.3、8.0、7.5、7.0、6.5 和 6.0）结合 96 小时。不同酸化情景中的快克可卡因引发细胞遗传毒性，这会影响暴露于环境相关浓度可卡因的贻贝的整体健康。这项研究产生了与海洋生物中CO ₂诱导的酸化和非法药物（快克可卡因）相关的生物标志物反应的第一个数据。