In obesity complicated by hypertension, multicellular processes integrate to orchestrate cardiac fibrosis; the underlying mechanisms, however, remain elusive. In this issue of JEM, Cheng et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20210252) describe adipocyte–macrophage collaboration to foster cardiac fibrosis through the actions of angiotensin II in obesity.

中文翻译：

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巨噬细胞-脂肪细胞通讯与心脏重塑

在并发高血压的肥胖症中，多细胞过程整合以协调心脏纤维化；然而，潜在的机制仍然难以捉摸。在本期JEM中，Cheng 等人。(2021. J. Exp. Med . https://doi.org/10.1084/jem.20210252) 描述了脂肪细胞-巨噬细胞协作通过血管紧张素 II 在肥胖中的作用促进心脏纤维化。