Type 2 diabetes is a risk factor for cognitive impairment. We examined the relation of glycemia, lipids, blood pressure (BP), hypertension history, and statin use with cognition in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).

Cross-sectional analyses from GRADE at baseline examined the association of glycemia (hemoglobin A_1c [HbA_1c]), LDL, systolic BP (SBP) and diastolic BP (DBP), hypertension history, and statin use with cognition assessed by the Spanish English Verbal Learning Test, letter and animal fluency tests, and Digit Symbol Substitution Test (DSST).

Among 5,047 GRADE participants, 5,018 (99.4%) completed cognitive assessments. Their mean age was 56.7 ± 10.0 years, and 36.4% were women. Mean diabetes duration was 4.0 ± 2.7 years. HbA_1c was not related to cognition. Higher LDL was related to modestly worse DSST scores, whereas statin use was related to modestly better DSST scores. SBP between 120 and 139 mmHg and DBP between 80 and 89 mmHg were related to modestly better DSST scores. Hypertension history was not related to cognition.

In people with type 2 diabetes of a mean duration of <5 years, lower LDL and statin use were related to modestly better executive cognitive function. SBP levels in the range of 120–139 mmHg and DBP levels in the range of 80–89 mmHg, but not lower levels, were related to modestly better executive function. These differences may not be clinically significant.

2型糖尿病是认知障碍的危险因素。我们检查了血糖、血脂、血压 (BP)、高血压病史和他汀类药物使用与糖尿病血糖降低方法中认知的关系：比较有效性研究 (GRADE)。

基线 GRADE 的横断面分析检查了血糖（血红蛋白 A _1c [HbA _1c ]）、低密度脂蛋白、收缩压 (SBP) 和舒张压 (DBP)、高血压病史和他汀类药物使用与认知的关联，由西班牙英语评估语言学习测试、字母和动物流利度测试以及数字符号替换测试 (DSST)。

在 5,047 名 GRADE 参与者中，5,018 人 (99.4%) 完成了认知评估。他们的平均年龄为 56.7 ± 10.0 岁，36.4% 为女性。平均糖尿病病程为 4.0 ± 2.7 年。HbA _1c与认知无关。较高的 LDL 与稍差的 DSST 评分有关，而使用他汀类药物与稍好的 DSST 评分有关。120 至 139 mmHg 之间的 SBP 和 80 至 89 mmHg 之间的 DBP 与稍高的 DSST 评分相关。高血压病史与认知无关。

在平均病程 <5 年的 2 型糖尿病患者中，较低的 LDL 和他汀类药物的使用与适度更好的执行认知功能有关。120-139 mmHg 范围内的 SBP 水平和 80-89 mmHg 范围内的 DBP 水平（但不是更低水平）与适度更好的执行功能有关。这些差异可能没有临床意义。