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Drug type and risk behaviors associated with non-fatal overdose among people who use drugs: a systematic review and meta-analysis
Journal of Addictive Diseases ( IF 2.065 ) Pub Date : 2021-07-21 , DOI: 10.1080/10550887.2021.1950262
Bahram Armoon 1, 2 , Neda SoleimanvandiAzar 3 , Mohammad Rostami 4 , Peter Higgs 5 , Azadeh Bayani 6 , Amir-Hossein Bayat 6 , Rasool Mohammadi 7 , Elahe Ahounbar 8 , Ladan Fattah Moghaddam 9
Affiliation  

Abstract

The present study aimed to determine the association between drug type, risk behaviors and non-fatal overdose among people who use drugs (PWUD). We searched for studies in English published before February 1, 2021, on PubMed, Scopus, Cochrane, and Web of Science to identify primary studies on the factors associated with non-fatal overdose among PWUD. After reviewing for study duplicates, the full-text of selected articles were assessed for eligibility using Population, Intervention, Comparator, Outcomes (PICO) criteria. After a detailed assessment of over 13,845 articles, a total of 49 studies met the eligibility criteria. We found that non-injection opioid use, heroin injection, cocaine use, concurrent use of buprenorphine and benzodiazepines, benzodiazepine use, incarceration, injecting drugs, and duration of injecting were associated with greater odds of non-fatal overdose among PWUD. The findings of the current meta-analysis support the requirement to improve suitable harm reduction strategies for drug users, such as peer-based overdose management, and further focusing on the need to balance the current emphasis on enforcement-based responses to illegal drug use with health-related interventions.



中文翻译:

吸毒者中与非致命性过量用药相关的药物类型和危险行为:系统评价和荟萃分析

摘要

本研究旨在确定吸毒者 (PWUD) 的药物类型、危险行为和非致命性过量用药之间的关联。我们检索了 2021 年 2 月 1 日之前在 PubMed、Scopus、Cochrane 和 Web of Science 上发表的英文研究,以确定与 PWUD 中非致命性过量相关因素的初步研究。在审查研究重复后,使用人口、干预、比较器、结果 (PICO) 标准评估所选文章的全文是否符合资格。在对超过 13,845 篇文章进行详细评估后,共有 49 项研究符合资格标准。我们发现非注射类阿片类药物使用、海洛因注射、可卡因使用、丁丙诺啡和苯二氮卓类药物同时使用、苯二氮卓类药物使用、监禁、注射毒品、在 PWUD 中,注射持续时间和注射持续时间与更大的非致命性过量的几率相关。当前荟萃分析的结果支持改进针对吸毒者的适当减害策略的要求,例如基于同伴的过量管理,并进一步强调需要平衡当前对非法吸毒的执法反应的强调与与健康有关的干预措施。

更新日期:2021-07-21
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