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Spontaneous activity in developing thalamic and cortical sensory networks
Neuron ( IF 16.2 ) Pub Date : 2021-07-21 , DOI: 10.1016/j.neuron.2021.06.026
Francisco J Martini 1 , Teresa Guillamón-Vivancos 1 , Verónica Moreno-Juan 1 , Miguel Valdeolmillos 1 , Guillermina López-Bendito 1
Affiliation  

Developing sensory circuits exhibit different patterns of spontaneous activity, patterns that are related to the construction and refinement of functional networks. During the development of different sensory modalities, spontaneous activity originates in the immature peripheral sensory structures and in the higher-order central structures, such as the thalamus and cortex. Certainly, the perinatal thalamus exhibits spontaneous calcium waves, a pattern of activity that is fundamental for the formation of sensory maps and for circuit plasticity. Here, we review our current understanding of the maturation of early (including embryonic) patterns of spontaneous activity and their influence on the assembly of thalamic and cortical sensory networks. Overall, the data currently available suggest similarities between the developmental trajectory of brain activity in experimental models and humans, which in the future may help to improve the early diagnosis of developmental disorders.



中文翻译:

发展丘脑和皮层感觉网络的自发活动

发展感觉回路表现出不同的自发活动模式,这些模式与功能网络的构建和细化有关。在不同感觉方式的发展过程中,自发活动起源于未成熟的外围感觉结构和高级中央结构,如丘脑和皮层。当然,围产期丘脑会表现出自发的钙波,这是一种对形成感觉图和电路可塑性至关重要的活动模式。在这里,我们回顾了我们目前对自发活动的早期(包括胚胎)模式的成熟及其对丘脑和皮层感觉网络组装的影响的理解。总体,

更新日期:2021-08-19
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