Metastases of solid tumors to the eye and ocular adnexa are rare. Herein, the authors describe the clinical, histologic, and immunohistochemical findings of a patient with a history of adenocarcinoma of the colon and a uterine carcinosarcoma (malignant mixed Müllerian tumor) who presented with proptosis and decreased vision. Positive staining with PAX-8, p16 and negative reaction for CK20 and CDX2 helped to establish the uterine origin of the metastasis. This rare case demonstrates the utility of immunohistochemical probes, especially in patients with a complex oncological history, where multiple primary sources of the metastasis are in the differential diagnosis.

中文翻译：

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转移性子宫癌肉瘤至眼眶。

实体瘤转移至眼睛和眼附件的情况很少见。在此，作者描述了一名有结肠腺癌和子宫癌肉瘤（恶性混合性苗勒氏管肿瘤）病史的患者的临床、组织学和免疫组织化学发现，该患者出现眼球突出和视力下降。PAX-8、p16 的阳性染色和 CK20 和 CDX2 的阴性反应有助于确定转移的子宫起源。这一罕见病例证明了免疫组织化学探针的实用性，特别是对于具有复杂肿瘤病史的患者，其中多个主要转移来源需要进行鉴别诊断。