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Neurovascular protection of salvianolic acid B and ginsenoside Rg1 combination against acute ischemic stroke in rats.
Neuroreport ( IF 1.7 ) Pub Date : 2021-07-19 , DOI: 10.1097/wnr.0000000000001706
Yao Fu 1, 2 , Rongrong Xing 2 , Linlin Wang 2 , Li Yang 1 , Baohong Jiang 2
Affiliation  

Ischemic stroke continues to be a major global health problem associated with considerable mortality and morbidity. Thus, it is still targeted by researchers for developing new strategies or drugs to alleviate the lesion of stroke. In the present study, both the permanent occlusion of the middle cerebral artery (MCAO) model and the restoration of cerebral blood flow after middle cerebral artery occlusion (CI/R) model were set up for evaluating the efficiency of salvianolic acid B and ginsenoside Rg1 combination (SalB-Rg1). SalB-Rg1 decreased infarct area through 3,5-triphenyltetrazolium chloride stain and improved neurological behavior through Longa Score or Left-Biased Swings on both MCAO rats and CI/R rats. Neural protection of SalB-Rg1 against ischemia or ischemic reperfusion injury was evidenced by the inhibition of nucleus pyknosis, liquefaction necrosis through H&E stain and Nissl stain. Furthermore, protection of SalB-Rg1 on blood-brain barrier (BBB) was more significant on CI/R rats, accompanying with the downregulation of matrix metalloproteinase-2 and matrix metalloproteinase-9, and recovery of zonula occludens-1 expression. These results provide compelling evidence that SalB-Rg1 holds the potential to be developed as an optimal therapeutic strategy to alleviate the injury of ischemia or ischemic reperfusion.

中文翻译:

丹酚酸 B 和人参皂苷 Rg1 组合对大鼠急性缺血性脑卒中的神经血管保护作用。

缺血性中风仍然是一个主要的全球健康问题,具有相当高的死亡率和发病率。因此,它仍然是研究人员开发新策略或药物来减轻中风病变的目标。本研究分别建立大脑中动脉永久闭塞(MCAO)模型和大脑中动脉闭塞后脑血流恢复(CI/R)模型来评价丹酚酸B和人参皂苷Rg1的疗效。组合(SalB-Rg1)。SalB-Rg1 通过 3,5-三苯基氯化四唑染色减少梗塞面积,并通过 Longa 评分或左偏摆动改善 MCAO 大鼠和 CI/R 大鼠的神经行为。通过H&E染色和尼氏染色抑制核固缩、液化坏死,证明了SalB-Rg1对缺血或缺血再灌注损伤的神经保护作用。此外,SalB-Rg1对血脑屏障(BBB)的保护作用在CI/R大鼠中更为显着,伴随着基质金属蛋白酶-2和基质金属蛋白酶-9的下调,以及闭合小带-1表达的恢复。这些结果提供了令人信服的证据,表明 SalB-Rg1 有潜力被开发为减轻缺血或缺血再灌注损伤的最佳治疗策略。
更新日期:2021-07-22
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