Cancer liquid biopsy encompassing circulating tumor cells (CTC), circulating tumor DNA (ctDNA) and/or tumor-derived exosomes (TEX) emerges as a novel approach to early detection, noninvasive monitoring of responses to therapy and predicting patient survival. TEX are a key component of liquid biopsy because they mimic tumor cells in their proteomic and genetic content. Two recent proteomic analyses of TEX released into plasma by melanoma cells confirms the potential of TEX as diagnostic and prognostic markers in melanoma.

中文翻译：

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血浆中黑色素瘤细胞衍生的外泌体的蛋白质组学特征：发现黑色素瘤进展的潜在生物标志物。

包含循环肿瘤细胞 (CTC)、循环肿瘤 DNA (ctDNA) 和/或肿瘤源性外泌体 (TEX) 的癌症液体活检成为一种早期检测、无创监测治疗反应和预测患者生存的新方法。TEX 是液体活检的关键组成部分，因为它们在蛋白质组和遗传内容方面模仿肿瘤细胞。最近对黑色素瘤细胞释放到血浆中的 TEX 进行的两项蛋白质组学分析证实了 TEX 作为黑色素瘤诊断和预后标记物的潜力。