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Genome mining for drug discovery: progress at the front end
Journal of Industrial Microbiology & Biotechnology ( IF 3.4 ) Pub Date : 2021-07-14 , DOI: 10.1093/jimb/kuab044
Richard H Baltz 1
Affiliation  

Microbial genome mining for drug discovery and development has been accelerating in recent years, driven by technical advancements in genome sequencing, bioinformatics, metabolomics/metabologenomics, and synthetic biology. Microbial genome mining is a multistep process that starts with the sequencing of microbes that encode multiple secondary metabolites and identifying new and novel secondary metabolite biosynthetic gene clusters (BGCs) to pursue. The initial steps in the process are critical for the overall success, and they encompass the most innovative new technologies to revitalize natural product discovery. As microbial genome mining has matured in recent years, unvalidated conjectures about what microbes to pursue, how to identify legitimate secondary metabolite BGCs, and how to sequence DNA to satisfactory levels of completion have been identified. The solutions to correct the misconceptions around these topics are beginning to be implemented.

中文翻译:

用于药物发现的基因组挖掘:前端的进展

近年来,在基因组测序、生物信息学、代谢组学/代谢基因组学和合成生物学技术进步的推动下,用于药物发现和开发的微生物基因组挖掘一直在加速。微生物基因组挖掘是一个多步骤过程,首先是对编码多种次级代谢物的微生物进行测序,并确定新的和新型的次级代谢物生物合成基因簇 (BGC)。该过程的初始步骤对于整体成功至关重要,它们包含最具创新性的新技术,以振兴天然产品的发现。随着近年来微生物基因组挖掘的成熟,关于追求什么微生物、如何识别合法的次级代谢物 BGC、以及如何对 DNA 进行测序以达到令人满意的完成水平。纠正围绕这些主题的误解的解决方案已开始实施。
更新日期:2021-07-14
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