Alzheimer's disease (AD) is the most prevalent dementia in the elderly, causing disability, physical, psychological, social, and economic damage to the individual, their families, and caregivers. Studies have shown some spices, such as saffron, rosemary, cinnamon, turmeric, and ginger, have antioxidant and anti-inflammatory properties that act in inhibiting the aggregation of acetylcholinesterase and amyloid in AD. For this reason, spices have been studied as beneficial sources against neurodegenerative diseases, including AD. In this sense, this study aims to present a review of some spices (Saffron, Rosemary, Cinnamon, Turmeric and Ginger) and their bioactive compounds, most consumed and investigated in the world regarding AD. In this article, scientific evidence is compiled in clinical trials in adults, the elderly, animals, and in vitro, on properties considered neuroprotective, having no or negative effects on neuroprotection of these spices and their bioactive compounds. The importance of this issue is based on the pharmacological treatment for AD that is still not very effective. In addition, the recommendations and prescriptions of these spices are still permeated by questioning and lack of robust evidence of their effects on neurodegeneration. The literature search suggests all spices included in this article have bioactive compounds with anti-inflammatory and antioxidant actions associated with neuroprotection. To date, the amounts of spice ingestion in humans are not uniform, and there is no consensus on its indication and chronic consumption guarantees safety and efficacy in neuroprotection. Therefore, clinical evidence on this topic is necessary to become a formal adjuvant treatment for AD.

阿尔茨海默病 (AD) 是老年人中最普遍的痴呆症，会对个人、他们的家人和照顾者造成残疾、身体、心理、社会和经济损害。研究表明，一些香料，如藏红花、迷迭香、肉桂、姜黄和生姜，具有抗氧化和抗炎特性，可抑制 AD 中乙酰胆碱酯酶和淀粉样蛋白的聚集。出于这个原因，香料已被研究为对抗神经退行性疾病（包括 AD）的有益来源。从这个意义上讲，本研究旨在回顾一些香料（藏红花、迷迭香、肉桂、姜黄和生姜）及其生物活性化合物，这些化合物在世界上最常被消费和研究的与 AD 相关。在本文中，在成人、老年人、动物和体外的临床试验中收集了科学证据，在被认为具有神经保护作用的特性上，对这些香料及其生物活性化合物的神经保护作用没有或有负面影响。这个问题的重要性是基于对 AD 的药物治疗仍然不是很有效。此外，这些香料的建议和处方仍然充斥着质疑和缺乏强有力的证据证明它们对神经变性的影响。文献检索表明，本文中包含的所有香料都具有生物活性化合物，具有与神经保护相关的抗炎和抗氧化作用。迄今为止，人类摄入香料的量并不统一，对其适应症也没有达成共识，长期食用可以保证神经保护的安全性和有效性。所以，