Studies on caregiver burden in patients with frontotemporal lobar degeneration are rare, differ methodologically and show variable results. Single center longitudinal pilot study on caregiver burden and potential risk factors in patients with behavioural variant frontotemporal dementia (bvFTD) and semantic (svPPA) and non-fluent variants (nfvPPA) primary progressive aphasia. Forty-six bvFTD, nine svPPA, and six nfvPPA patients and caring relatives were analysed for up to 2 years using the Mini-Mental State Examination as global measure for cognitive performance, Frontal Assessment Battery (frontal lobe functions), Frontal Behavioural Inventory (personality and behaviour), Neuropsychiatric Inventory (dementia-related neuropsychiatric symptoms), Barthel Index and Lawton IADL Scale (basic and instrumental activities of daily living), the Caregiver Strain Index (CSI), and in most participants also the Zarit Burden Interview (ZBI). CSI baseline sum scores were highest in bvFTD (mean ± SD 5.5 ± 3.4, median 5, IQR 6), intermediate in svPPA (2.9 ± 2.3; 3; 3.5) and low in nfvPPA (1.6 ± 2.1; 1; 2). Similar differences of caregiver burden were found using the ZBI. During follow-up, CSI and ZBI sum scores deteriorated in svPPA, not in bvFTD and nfvPPA, and correlated significantly with personality and behaviour, neuropsychiatric symptoms, caregiver age, and instrumental, but not basic activities of daily living, Mini-Mental State Examination scores or frontal lobe functions. This study reveals differences in caregiver burden in variants of frontotemporal lobar degeneration. Caregivers should be systematically asked for caregiver burden from the time of the diagnosis to provide comprehensive support in time.

对额颞叶变性患者照顾者负担的研究很少见，方法不同，结果也不尽相同。关于行为变异额颞叶痴呆 (bvFTD) 和语义 (svPPA) 和非流利变异 (nfvPPA) 原发性进行性失语症患者的照顾者负担和潜在危险因素的单中心纵向试点研究。46 名 bvFTD、9 名 svPPA 和 6 名 nfvPPA 患者和有爱心的亲属进行了长达 2 年的分析，使用简易精神状态检查作为认知表现的全球测量、额叶评估电池（额叶功能）、额叶行为量表（人格和行为）、神经精神量表（痴呆相关的神经精神症状）、Barthel 指数和劳顿 IADL 量表（日常生活的基本和工具性活动），看护者压力指数 (CSI)，大多数参与者还有 Zarit 负担访谈 (ZBI)。CSI 基线总分在 bvFTD 中最高（平均值 ± SD 5.5 ± 3.4，中位数 5，IQR 6），在 svPPA 中处于中等水平（2.9 ± 2.3；3；3.5），在 nfvPPA 中处于低水平（1.6 ± 2.1；1；2）。使用 ZBI 发现了类似的照顾者负担差异。在随访期间，CSI 和 ZBI 总分在 svPPA 中下降，在 bvFTD 和 nfvPPA 中没有下降，并且与人格和行为、神经精神症状、看护者年龄、工具性但不是基本的日常生活活动、简易精神状态检查显着相关分数或额叶功能。本研究揭示了额颞叶变性变体中照顾者负担的差异。