The delivery of hydrophobic therapeutic agents to tumors is a challenge in the treatment of cancers. Here, we review recent advances in coiled-coil protein origami and discuss a proposed programmable protein origami structure, switchable by a protein kinase A/phosphatase switch, as an example of functionalization for designing future protein nanorobots.

中文翻译：

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基于蛋白质的纳米机器人的药理学功能化作为癌症药物递送的新工具

将疏水性治疗剂递送至肿瘤是治疗癌症的挑战。在这里，我们回顾了卷曲螺旋蛋白质折纸的最新进展，并讨论了一种可通过蛋白激酶 A/磷酸酶开关切换的可编程蛋白质折纸结构，作为设计未来蛋白质纳米机器人的功能化示例。