Objectives: To explore the association between resting state functional connectivity and accelerometer-measured physical activity in pediatric concussion. Methods: Fourteen children with concussion (aged 14.54 ± 2.39 years, 8 female) were included in this secondary data-analysis. Participants had neuroimaging at 15.3 ± 6.7 days post-injury and subsequently a mean of 11.1 ± 5.0 days of accelerometer data. Intra-network connectivity of the default mode network (DMN), sensorimotor network (SMN), salience network (SN), and fronto-parietal network (FPN) was computed. Results: Per general linear models, only intra-network connectivity of the DMN was associated with habitual physical activity levels. More specifically, increased intra-network connectivity of the DMN was significantly associated with higher levels of subsequent accelerometer-measured light physical activity (F(2, 11) = 7.053, p = 0.011, Ra2 = 0.562; β = 0.469), moderate physical activity (F(2, 11) = 7.053, p = 0.011, Ra2 = 0.562; β = 0.725), and vigorous physical activity (F(2, 11) = 10.855, p = 0.002, Ra2 = 0.664; β = 0.79). Intra-network connectivity of the DMN did not significantly predict sedentary time. Likewise, the SMN, SA, and FPN were not significantly associated with either sedentary time or physical activity. Conclusion: These findings suggest that there is a positive association between the intra-network connectivity of the DMN and device-measured physical activity in children with concussion. Given that DMN impairment can be commonplace following concussion, this may be associated with lower levels of habitual physical activity, which can preclude children from experiencing the symptom-improving benefits of sub-maximal physical activity.

中文翻译：

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探索静息状态网络内连接与加速计测量的儿科脑震荡身体活动之间的关系：一项队列研究。

目的：探讨静息状态功能连接与加速度计测量的儿科脑震荡体力活动之间的关联。方法：14 名脑震荡儿童（年龄 14.54 ± 2.39 岁，8 名女性）被纳入该次要数据分析。参与者在受伤后 15.3 ± 6.7 天进行神经影像学检查，随后平均 11.1 ± 5.0 天的加速度计数据。计算了默认模式网络 (DMN)、感觉运动网络 (SMN)、显着性网络 (SN) 和额顶叶网络 (FPN) 的网络内连接。结果：根据一般线性模型，只有 DMN 的网络内连接与习惯性身体活动水平相关。进一步来说，DMN 网络内连接性的增加与更高水平的后续加速度计测量的轻体力活动显着相关（F(2, 11) = 7.053, p = 0.011, Ra2 = 0.562; β = 0.469），中等体力活动（F (2, 11) = 7.053, p = 0.011, Ra2 = 0.562; β = 0.725) 和剧烈的体力活动 (F(2, 11) = 10.855, p = 0.002, Ra2 = 0.664; β = 0.79)。DMN 的网络内连接没有显着预测久坐时间。同样，SMN、SA 和 FPN 与久坐时间或体力活动均无显着相关性。结论：这些发现表明，在脑震荡儿童中，DMN 的网络内连接与设备测量的身体活动之间存在正相关。鉴于 DMN 损伤在脑震荡后很常见，