Abstract

Context

Pseudocedrela kotschyi (Schweinf) Harms (Meliaceae) is an important medicinal plant found in tropical and subtropical countries of Africa. Traditionally, P. kotschyi is used in the treatment of various diseases including diabetes, malaria, abdominal pain and diarrhoea.

Objective

To provide an overview of traditional medicinal claims, pharmacological properties, and phytochemical principles of P. kotschyi as a basis for its clinical applications and further research and development of new drugs.

Methods

Through interpreting already published scientific manuscripts retrieved from different scientific search engines, namely, Medline, PubMed, EMBASE, Science Direct and Google scholar databases, an up-to-date review on the medicinal potentials of P. kotschyi from inception until September, 2020 was compiled. ‘Pseudocedrela kotschyi’, ‘traditional uses’, ‘pharmacological properties’ and ‘chemical constituents’ were used as search words.

Results

At present, more than 30 chemical constituents have been isolated and identified from the root and stem bark of P. kotschyi, among which limonoids and triterpenes are the main active constituents. Based on prior research, P. kotschyi has been reported to possess anti-inflammatory, analgesic, antipyretic, anthelminthic, antimalaria, anti-leishmaniasis, anti-trypanosomiasis, hepatoprotective, antioxidant, antidiabetic, antidiarrheal, antimicrobial, and anticancer effects.

Conclusions

P. kotschyi is reported to be effective in treating a variety of diseases. Current phytochemical and pharmacological studies mainly focus on antimalaria, anti-leishmaniasis, anti-trypanosomiasis and anticancer potential of the root and stem bark of P. kotschyi. Although experimental data support the beneficial medicinal properties of this plant, there is still a paucity of information on its toxicity profile. Nonetheless, this review provides the basis for future research work.

中文翻译：

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Pseudocedrela kotschyi：民族药用、药理学和植物化学综述

摘要

语境

Pseudocedrela kotschyi (Schweinf) Harms (Meliaceae) 是一种重要的药用植物，分布于非洲热带和亚热带国家。传统上，P. kotschyi用于治疗各种疾病，包括糖尿病、疟疾、腹痛和腹泻。

客观的

概述P. kotschyi的传统药用功效、药理特性和植物化学原理，作为其临床应用和新药进一步研发的基础。

方法

通过解读从不同科学搜索引擎（即 Medline、PubMed、EMBASE、Science Direct 和 Google 学术数据库）检索到的已发表科学手稿，对从开始到 2020 年 9 月的P. kotschyi药用潜力的最新评论是编译。“ Pseudocedrela kotschyi ”、“传统用途”、“药理特性”和“化学成分”被用作搜索词。

结果

目前已从高粱根皮和茎皮中分离鉴定出30多种化学成分，其中柠檬苦素和三萜类是主要活性成分。根据先前的研究，据报道， P. kotschyi具有抗炎、镇痛、解热、驱虫、抗疟疾、抗利什曼病、抗锥虫病、保肝、抗氧化、抗糖尿病、止泻、抗菌和抗癌作用。

结论

据报道， P. kotschyi可有效治疗多种疾病。目前的植物化学和药理学研究主要集中在P. kotschyi根和茎皮的抗疟疾、抗利什曼病、抗锥虫病和抗癌潜力。尽管实验数据支持这种植物的有益药用特性，但仍然缺乏关于其毒性特征的信息。尽管如此，这篇综述为未来的研究工作提供了基础。