Myeloid suppressor cells (MDSCs) are an important class of immune-regulating cells that can suppress T cell function. Most of our knowledge about the function of MDSC comes from studies of cancer models. Recent studies, however, have greatly contributed to the description of MDSC involvement in autoimmune diseases. They are known as a cell population that may negatively affect immune responses by regulating the function of CD4⁺ and CD8⁺ cells, which makes them an attractive target for autoimmune diseases therapy. However, many questions about MDSC activation, differentiation, and inhibitory functions remain unanswered. In this study, we have summarized the role of MDSCs in various autoimmune diseases, and the potential of targeting them for therapeutic benefits has been discussed.

髓系抑制细胞（MDSCs）是一类重要的免疫调节细胞，可抑制T细胞功能。我们关于 MDSC 功能的大部分知识来自对癌症模型的研究。然而，最近的研究极大地促进了 MDSC 参与自身免疫性疾病的描述。它们被称为细胞群，可通过调节 CD4 ⁺和 CD8 ⁺细胞的功能对免疫反应产生负面影响，这使它们成为自身免疫性疾病治疗的有吸引力的目标。然而，关于 MDSC 激活、分化和抑制功能的许多问题仍未得到解答。在这项研究中，我们总结了 MDSC 在各种自身免疫性疾病中的作用，并讨论了靶向它们以获得治疗益处的潜力。