TLR signaling is critical for broad scale immune recognition of pathogens and/or danger molecules. TLRs are particularly important for the activation and the maturation of cells comprising the innate immune response. In recent years it has become apparent that several different TLRs regulate the function of lymphocytes as well, albeit to a lesser degree compared to innate immunity. TLR2 heterodimerizes with either TLR1 or TLR6 to broadly recognize bacterial lipopeptides as well as several danger-associated molecular patterns. In general, TLR2 signaling promotes immune cell activation leading to tissue inflammation, which is advantageous for combating an infection. Conversely, inappropriate or dysfunctional TLR2 signaling leading to an overactive inflammatory response could be detrimental during sterile inflammation and autoimmune disease. This review will highlight and discuss recent research advances linking TLR2 engagement to autoimmune inflammation.

中文翻译：

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自身免疫性炎症中的 Toll 样受体 2。

TLR 信号对于病原体和/或危险分子的大规模免疫识别至关重要。TLRs 对于包含先天免疫反应的细胞的激活和成熟尤为重要。近年来，很明显几种不同的 TLR 也调节淋巴细胞的功能，尽管与先天免疫相比程度较低。TLR2 与 TLR1 或 TLR6 异二聚化以广泛识别细菌脂肽以及几种与危险相关的分子模式。一般来说，TLR2 信号促进免疫细胞活化，导致组织炎症，这有利于对抗感染。相反，导致过度活跃的炎症反应的不适当或功能失调的 TLR2 信号可能在无菌炎症和自身免疫性疾病期间有害。