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Mechanisms Underlying the Role of Myeloid-Derived Suppressor Cells in Clinical Diseases: Good or Bad.
Immune Network ( IF 6 ) Pub Date : 2021-05-26 , DOI: 10.4110/in.2021.21.e21
Yongtong Ge 1 , Dalei Cheng 1 , Qingzhi Jia 2 , Huabao Xiong 1 , Junfeng Zhang 1
Affiliation  

Myeloid-derived suppressor cells (MDSCs) have strong immunosuppressive activity and are morphologically similar to conventional monocytes and granulocytes. The development and classification of these cells have, however, been controversial. The activation network of MDSCs is relatively complex, and their mechanism of action is poorly understood, creating an avenue for further research. In recent years, MDSCs have been found to play an important role in immune regulation and in effectively inhibiting the activity of effector lymphocytes. Under certain conditions, particularly in the case of tissue damage or inflammation, MDSCs play a leading role in the immune response of the central nervous system. In cancer, however, this can lead to tumor immune evasion and the development of related diseases. Under cancerous conditions, tumors often alter bone marrow formation, thus affecting progenitor cell differentiation, and ultimately, MDSC accumulation. MDSCs are important contributors to tumor progression and play a key role in promoting tumor growth and metastasis, and even reduce the efficacy of immunotherapy. Currently, a number of studies have demonstrated that MDSCs play a key regulatory role in many clinical diseases. In light of these studies, this review discusses the origin of MDSCs, the mechanisms underlying their activation, their role in a variety of clinical diseases, and their function in immune response regulation.

中文翻译:

骨髓源性抑制细胞在临床疾病中作用的机制:好还是坏。

骨髓源性抑制细胞(MDSC)具有很强的免疫抑制活性,形态与常规单核细胞和粒细胞相似。然而,这些细胞的发育和分类一直存在争议。MDSCs的激活网络相对复杂,其作用机制知之甚少,为进一步研究创造了途径。近年来,人们发现MDSCs在免疫调节和有效抑制效应淋巴细胞活性方面发挥着重要作用。在某些条件下,特别是在组织损伤或炎症的情况下,MDSC在中枢神经系统的免疫反应中发挥主导作用。然而,在癌症中,这可能导致肿瘤免疫逃避和相关疾病的发展。在癌症条件下,肿瘤经常改变骨髓形成,从而影响祖细胞分化,并最终影响 MDSC 积累。MDSC是肿瘤进展的重要贡献者,在促进肿瘤生长和转移中发挥关键作用,甚至降低免疫治疗的疗效。目前,多项研究表明MDSCs在多种临床疾病中发挥着关键的调节作用。根据这些研究,本文讨论了 MDSC 的起源、其激活机制、其在多种临床疾病中的作用以及其在免疫反应调节中的功能。
更新日期:2021-07-21
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