Purpose: To evaluate the histopathological characteristics of clinically advanced retinoblastoma (RB) and its relationship with tumor differentiation. Methods: This was a cross-sectional study of primary enucleated group D/E intraocular RB using medical records from 2017 to 2020 in a tertiary referral hospital. Cases with incomplete histopathological results were excluded. Tumors were classified into well, moderately, and poorly differentiated and undifferentiated. High-risk histopathological features were classified as per Thaung and Karaa [Community Eye Health. 2018;31(101):17–3]. Results: This study included 121 patients (129 eyes), of which 32.2% were diagnosed at 25–36 months. High-risk features (HRFs) were found in 100/129 eyes, and of 73 complete histopathological results, the 2 most common HRFs were postlaminar optic nerve invasion and massive choroidal invasion. RB was poorly differentiated in 69.9% and well differentiated in 12.3% of eyes. There was no statistically significant association between any HRFs and tumor differentiation, with age #x3e;2 years associated with tumor differentiation (p #x3c; 0.05). Conclusion: The frequency of HRFs is 77.5% of primary enucleated eyes, mainly poorly and undifferentiated cells, particularly in children aged #x3e;2 years old.
Ocul Oncol Pathol

中文翻译：

---

印度尼西亚西爪哇一家三级医院治疗的视网膜母细胞瘤的高危组织病理学特征

目的：评估临床晚期视网膜母细胞瘤（RB）的组织病理学特征及其与肿瘤分化的关系。方法：这是一项使用 2017 年至 2020 年在三级转诊医院的病历对原发性去核组 D/E 眼内 RB 进行的横断面研究。组织病理学结果不完整的病例被排除在外。肿瘤分为高分化、中分化、低分化和未分化。根据 Thaung 和 Karaa [社区眼健康. 2018;31(101):17-3]。结果：这项研究包括 121 名患者（129 只眼），其中 32.2% 在 25-36 个月时被诊断出来。在 100/129 只眼中发现了高危特征 (HRF)，在 73 个完整的组织病理学结果中，最常见的 2 个 HRF 是椎板后视神经侵犯和大块脉络膜侵犯。RB 在 69.9% 的眼睛中分化差，在 12.3% 的眼睛中分化良好。任何 HRF 与肿瘤分化之间没有统计学上的显着关联，年龄 #x3e;2 岁与肿瘤分化相关（p #x3c; 0.05）。结论：原发性去核眼的 HRF 频率为 77.5%，主要是低分化细胞和未分化细胞，特别是在 #x3e;2 岁儿童中。
眼肿瘤病理