The detection of sulfamethoxazole, an antibacterial sulfonamide drug, is a very effective with antibiotic properties, and commonly used in the treatment of a variety of infections. Due to the importance in diseases treatment of humans and also of animals, the development of techniques for its quantification in body fluids is highly desirable. A voltammetric sensor is described for the determination of the antibiotic sulfamethoxazole. It is based on the use of a carbon paste electrode modified with a Fe₃O₄/ZIF-67 nanocomposite and ionic liquid (IL) 1-Butyl-3-methylimidazolium hexafluorophosphate (Fe₃O₄/ZIF-67/ILCPE). The morphology and structure of the nanocomposite were characterized by Fourier-transform infrared spectroscopy (FT-IR), x-ray diffraction (XRD), transmission electron microscopy(TEM) and field emission scanning electron microscopy (FESEM). Under the optimal conditions, the response of the electrode, typically measured between 0.74 and 1.1 V (vs. Ag/AgCl), increases linearly in the 0.01−520.0 µM sulfamethoxazole concentration range, and the lower detection limit is 5.0 nM. Moreover, this electrode could substantially be applied for the analysis of sulfamethoxazole in the real samples (e.g., urine, tap water and river water).

磺胺甲恶唑的检测是一种抗菌磺胺类药物，是一种非常有效的抗生素，常用于治疗多种感染。由于在人类和动物的疾病治疗中的重要性，非常需要开发用于其在体液中进行量化的技术。描述了一种用于测定抗生素磺胺甲恶唑的伏安传感器。它基于使用 Fe ₃ O ₄ /ZIF-67 纳米复合材料和离子液体 (IL) 1-丁基-3-甲基咪唑鎓六氟磷酸盐 (Fe ₃ O ₄/ZIF-67/ILCPE）。采用傅里叶变换红外光谱（FT-IR）、X射线衍射（XRD）、透射电子显微镜（TEM）和场发射扫描电子显微镜（FESEM）对纳米复合材料的形貌和结构进行了表征。在最佳条件下，电极的响应通常在 0.74 和 1.1 V（相对于 Ag/AgCl）之间测量，在 0.01-520.0 µM 磺胺甲恶唑浓度范围内线性增加，检测下限为 5.0 nM。此外，该电极基本上可用于实际样品（如尿液、自来水和河水）中磺胺甲恶唑的分析。