Background: Paclitaxel is a key antineoplastic agent in the treatment of breast cancer and many other malignancies. However, paclitaxel-induced peripheral neuropathy (PIPN) is a common adverse event that occurs with paclitaxel therapy and frequently causes considerable pain and a decline in patients' quality of life. Single nucleotide polymorphisms (SNPs) in the ABCB1 gene have been frequently associated with increased severity of PIPN. However, the validity of ABCB1 SNP markers to predict the incidence of PIPN has not been confirmed.

中文翻译：

---

ABCB1 单核苷酸多态性基因型作为紫杉醇诱导的乳腺癌周围神经病变的预测因子

背景：紫杉醇是治疗乳腺癌和许多其他恶性肿瘤的关键抗肿瘤药物。然而，紫杉醇诱导的周围神经病变 (PIPN) 是紫杉醇治疗中常见的不良事件，经常引起相当大的疼痛和患者生活质量的下降。ABCB1基因中的单核苷酸多态性 (SNP)经常与 PIPN 的严重程度增加有关。然而， ABCB1 SNP 标记预测 PIPN 发生率的有效性尚未得到证实。